Alcohol Center for Translational Genetics (ACTG)

描述（由申请人提供）：行政核心将执行所有4个研究组件（组件5-8）和试点项目（组件9）的集中管理功能。它还将协调科学支助核心的活动（组成部分2-4）。计划咨询委员会将提供科学监督，执行委员会将对ACTG活动做出行政决策。执行委员会将设定目标，评估一般科学研究方向的进展，并监督中心活动所有领域的质量控制机制。还将监督转基因动物生产、行为测定、用于基因沉默和转基因表达的病毒载体生产、成像和组织学分析以及基因组学服务。核心还将赞助丰富的活动，包括演讲嘉宾，一个新的课程成瘾的神经生物学的UCSF神经科学研究生课程，和一个ACTG网站，宣传ACTG赞助的活动，工作人员的开放和链接到其他组织的网站。在行政核心内将有两条行政责任线。梅辛博士，中心主任，将监督所有中心的行政活动和中心的预算的一般协调。科学主任Heberlein博士将监督科学方向的协调和未来规划。

DESCRIPTION (Provided by applicant): The Administrative Core will perform the centralized administrative functions for all 4 Research Components (Components 5-8) and the Pilot Projects (Component 9). It also will coordinate the activities of the Scientific Support Cores (Components 2-4). The Program Advisory Board will provide scientific oversight, and the Executive Committee will make executive decisions regarding ACTG activities. The Executive Committee will set goals, evaluate progress toward general scientific research directions, and oversee quality control mechanisms in all areas of Center activity. Oversight also will be provided for transgenic animal production, behavioral assays, production of viral vectors for gene silencing and transgenic expression, imaging and histological analyses, and genomics services. The Core will also sponsor enrichment activities, including guest speakers, a new course on the Neurobiology of Addiction for the UCSF Neuroscience Graduate Program, and an ACTG website to publicize ACTG-sponsored events, staff openings and links to other organizations' websites. There will be two lines of administrative responsibility within the Administrative Core. Dr. Messing, the Center Director, will supervise the general coordination of all Center administrative activities and the Center's budget. Dr. Heberlein, the Scientific Director, will supervise the coordination of and future planning for scientific directions.