Wake Forest Translational Alcohol Research Center (WF-TARC)

维克森林转化酒精研究中心 (WF-TARC)

• 批准号: 10526640
• 负责人: JEFFREY L WEINER
• 金额: $ 160.03万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-12-10 至 2027-11-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10526640
• 关键词: Acceleration; Adolescent; Alcohol consumption; Alcohols; Animal Model; Animals; Award; Behavior; Behavioral; Biometry; Brain; Collaborations; Communication; Community Health Education; Development; Diagnosis; Disease; Education; Education and Outreach; Ensure; Experimental Designs; Faculty; Funding; Goals; Grant; Growth; Healthcare Systems; Human; Human Subject Research; Individual; Infrastructure; Institution; Knowledge; Leadership; Learning; Measures; Methods; Molecular; Neurobiology; Pilot Projects; Play; Population; Populations at Risk; Postdoctoral Fellow; Pre-Clinical Model; Productivity; Research; Research Design; Research Methodology; Research Personnel; Research Project Grants; Research Support; Resources; Risk; Rodent; Role; Science; Sleep disturbances; Students; Substance Use Disorder; System; Talents; Translational Research; Translations; Treatment outcome; Work; addiction; alcohol abuse therapy; alcohol research; alcohol use disorder; behavioral study; drinking behavior; educational atmosphere; effective therapy; evidence base; forest; human model; improved; innovation; medical schools; morphogens; multidisciplinary; neural; neural correlate; neurodevelopment; next generation; nonhuman primate; novel; novel strategies; novel therapeutic intervention; predictive modeling; programs; recruit; resilience; success; training opportunity; translational therapeutics

WAKE FOREST TRANSLATIONAL ALCOHOL RESEARCH CENTER (WF-TARC) OVERALL SUMMARY The central goal of the Wake Forest Translational Alcohol Research Center (WF-TARC) is to employ integrated, translational animal and human subjects research to study behavioral correlates and neurobiological substrates associated with vulnerability and resilience to alcohol use disorder (AUD). This Center builds on a highly productive translational alcohol research program at WFSM that led to the awarding of this P50 grant in 2017. The WF-TARC is comprised of four research projects and two cores. An administrative core provides the leadership and infrastructure needed to ensure integration across all research projects. This core also provides biostatistical support and promotes interactions and communication between this Center and the many other addiction-related research and educational programs at Wake Forest School of Medicine (WFSM). A pilot project core serves to advance the goals and objectives of the WF-TARC. This core funds projects each year to attract new investigators to bring their talent and expertise to the study of AUD vulnerability. The unifying research focus of the WF-TARC is to leverage the unique strengths and advantages of animal and human subjects research to study behavioral correlates of AUD vulnerability and identify neurobiological adaptations that contribute to this heightened risk of developing this disorder. These studies employ cutting- edge, multidisciplinary experimental approaches spanning molecular, cellular, circuit, and whole-brain analyses. Importantly, studies in each project are also seeking to improve AUD treatment outcomes. The well- integrated conceptual framework and research design facilitates backward and forward interactions across all projects, facilitating the rapid translation of therapeutic discoveries from animals to humans. The WF-TARC leverages a well-established, highly collaborative translational alcohol research program at WFSM and benefits from a strong and growing institutional focus on alcohol and substance use disorders. This Center will continue to enhance the outstanding educational environment at our institution, providing unique training opportunities for the students and postdoctoral who will become the next generation of translational alcohol researchers. Finally, the innovative research supported by the WF-TARC may lead to improved evidence-based therapies for individuals who are at greatest risk of developing AUD, individuals who are particularly ill-served by current AUD treatment options.

维克森林翻译酒精研究中心 (WF-TARC) 总体总结 维克森林转化酒精研究中心 (WF-TARC) 的中心目标是雇用 综合的、转化性的动物和人类受试者研究，以研究行为相关性和 与酒精使用障碍（AUD）的脆弱性和恢复力相关的神经生物学底物。这 该中心建立在 WFSM 高效转化酒精研究项目的基础上，该项目导致了该奖项 2017 年 P50 赠款的一部分。 WF-TARC 由四个研究项目和两个核心组成。管理核心提供 确保所有研究项目的整合所需的领导力和基础设施。该核心还提供 生物统计支持并促进该中心与许多其他中心之间的互动和交流 维克森林医学院 (WFSM) 的成瘾相关研究和教育项目。一名飞行员 项目核心旨在推进 WF-TARC 的目的和目标。该核心每年资助项目 吸引新的研究人员将他们的才能和专业知识用于 AUD 脆弱性的研究。 WF-TARC 的统一研究重点是利用动物的独特优势和优势 和人类受试者研究，以研究 AUD 脆弱性的行为相关性并确定神经生物学 导致患这种疾病的风险增加的适应。这些研究采用了切割- 跨越分子、细胞、电路和全脑的边缘、多学科实验方法 分析。重要的是，每个项目的研究也在寻求改善 AUD 治疗结果。井- 综合概念框架和研究设计促进了所有方面的前后向互动 项目，促进治疗发现从动物到人类的快速转化。 WF-TARC 利用完善的、高度协作的转化酒精研究项目 WFSM 并受益于对酒精和药物滥用障碍的强烈且不断增长的机构关注。 该中心将继续改善我们机构优秀的教育环境，提供 为将成为下一代的学生和博士后提供独特的培训机会 转化酒精研究人员。最后，WF-TARC 支持的创新研究可能会导致 针对 AUD 风险最大的个体改进基于证据的治疗方法 目前的 AUD 治疗方案尤其不适用于这些人群。