Wake Forest Translational Alcohol Research Center (WF-TARC)
维克森林转化酒精研究中心 (WF-TARC)
基本信息
- 批准号:10526640
- 负责人:
- 金额:$ 160.03万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-12-10 至 2027-11-30
- 项目状态:未结题
- 来源:
- 关键词:AccelerationAdolescentAlcohol consumptionAlcoholsAnimal ModelAnimalsAwardBehaviorBehavioralBiometryBrainCollaborationsCommunicationCommunity Health EducationDevelopmentDiagnosisDiseaseEducationEducation and OutreachEnsureExperimental DesignsFacultyFundingGoalsGrantGrowthHealthcare SystemsHumanHuman Subject ResearchIndividualInfrastructureInstitutionKnowledgeLeadershipLearningMeasuresMethodsMolecularNeurobiologyPilot ProjectsPlayPopulationPopulations at RiskPostdoctoral FellowPre-Clinical ModelProductivityResearchResearch DesignResearch MethodologyResearch PersonnelResearch Project GrantsResearch SupportResourcesRiskRodentRoleScienceSleep disturbancesStudentsSubstance Use DisorderSystemTalentsTranslational ResearchTranslationsTreatment outcomeWorkaddictionalcohol abuse therapyalcohol researchalcohol use disorderbehavioral studydrinking behavioreducational atmosphereeffective therapyevidence baseforesthuman modelimprovedinnovationmedical schoolsmorphogensmultidisciplinaryneuralneural correlateneurodevelopmentnext generationnonhuman primatenovelnovel strategiesnovel therapeutic interventionpredictive modelingprogramsrecruitresiliencesuccesstraining opportunitytranslational therapeutics
项目摘要
WAKE FOREST TRANSLATIONAL ALCOHOL RESEARCH CENTER (WF-TARC)
OVERALL SUMMARY
The central goal of the Wake Forest Translational Alcohol Research Center (WF-TARC) is to employ
integrated, translational animal and human subjects research to study behavioral correlates and
neurobiological substrates associated with vulnerability and resilience to alcohol use disorder (AUD). This
Center builds on a highly productive translational alcohol research program at WFSM that led to the awarding
of this P50 grant in 2017.
The WF-TARC is comprised of four research projects and two cores. An administrative core provides the
leadership and infrastructure needed to ensure integration across all research projects. This core also provides
biostatistical support and promotes interactions and communication between this Center and the many other
addiction-related research and educational programs at Wake Forest School of Medicine (WFSM). A pilot
project core serves to advance the goals and objectives of the WF-TARC. This core funds projects each year
to attract new investigators to bring their talent and expertise to the study of AUD vulnerability.
The unifying research focus of the WF-TARC is to leverage the unique strengths and advantages of animal
and human subjects research to study behavioral correlates of AUD vulnerability and identify neurobiological
adaptations that contribute to this heightened risk of developing this disorder. These studies employ cutting-
edge, multidisciplinary experimental approaches spanning molecular, cellular, circuit, and whole-brain
analyses. Importantly, studies in each project are also seeking to improve AUD treatment outcomes. The well-
integrated conceptual framework and research design facilitates backward and forward interactions across all
projects, facilitating the rapid translation of therapeutic discoveries from animals to humans.
The WF-TARC leverages a well-established, highly collaborative translational alcohol research program at
WFSM and benefits from a strong and growing institutional focus on alcohol and substance use disorders.
This Center will continue to enhance the outstanding educational environment at our institution, providing
unique training opportunities for the students and postdoctoral who will become the next generation of
translational alcohol researchers. Finally, the innovative research supported by the WF-TARC may lead to
improved evidence-based therapies for individuals who are at greatest risk of developing AUD, individuals who
are particularly ill-served by current AUD treatment options.
维克森林翻译酒精研究中心(WF-TARC)
总体汇总
维克森林酒精转化研究中心(WF-TARC)的中心目标是雇用
综合的、转化的动物和人类受试者研究,以研究行为相关性,
与酒精使用障碍(AUD)的脆弱性和恢复力相关的神经生物学底物。这
中心建立在一个高效的翻译酒精研究计划在WFSM,导致授予
2017年的P50补助金。
WF-TARC由四个研究项目和两个核心组成。管理核心提供
领导力和基础设施,以确保所有研究项目的整合。该核心还提供
生物统计支持和促进本中心和许多其他中心之间的互动和沟通
维克森林医学院(WFSM)的成瘾相关研究和教育项目。一个试点
项目核心用于推进TARC工作组的目标和目的。这些核心资金每年用于
吸引新的调查人员将他们的才能和专业知识用于研究澳元的脆弱性。
WF-TARC的统一研究重点是利用动物的独特优势和优势
研究AUD脆弱性的行为相关性,并确定神经生物学
这些适应性改变导致了这种疾病的发生。这些研究采用切割-
边缘,跨分子,细胞,电路和全脑的多学科实验方法
分析。重要的是,每个项目的研究也在寻求改善AUD治疗结果。井-
综合概念框架和研究设计促进了所有领域的向后和向前互动
项目,促进治疗发现从动物到人类的快速翻译。
WF-TARC利用一个完善的,高度合作的翻译酒精研究计划,
WFSM和受益于一个强大的和不断增长的机构重点酒精和药物使用障碍。
该中心将继续加强我们机构的优秀教育环境,提供
独特的培训机会,为学生和博士后谁将成为下一代的
翻译酒精研究人员。最后,WF-TARC支持的创新研究可能会导致
改善对发展AUD风险最大的个体的循证疗法,
目前的AUD治疗方案尤其不佳。
项目成果
期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('JEFFREY L WEINER', 18)}}的其他基金
Project 4: Adolescent Social Isolation Increases Vulnerability to the Behavioral and Neurobiological Consequences of Chronic Ethanol Exposure in Male and Female Rats
项目 4:青少年社会孤立增加了雄性和雌性大鼠对慢性乙醇暴露的行为和神经生物学后果的脆弱性
- 批准号:
10310704 - 财政年份:2017
- 资助金额:
$ 160.03万 - 项目类别:
Project 4: Convergent behavioral and neurobiological adaptations promoted by rodent models of vulnerability to alcohol use disorder and post-traumatic stress disorder
项目 4:易患酒精使用障碍和创伤后应激障碍的啮齿动物模型促进趋同的行为和神经生物学适应
- 批准号:
10526646 - 财政年份:2017
- 资助金额:
$ 160.03万 - 项目类别:
Neural Substrates of Comorbid Alcohol Use Disorder and Post-Traumatic Stress Disorder
共病酒精使用障碍和创伤后应激障碍的神经基质
- 批准号:
10188342 - 财政年份:2017
- 资助金额:
$ 160.03万 - 项目类别:
Wake Forest Translational Alcohol Research Center (WF-TARC)
维克森林转化酒精研究中心 (WF-TARC)
- 批准号:
10310693 - 财政年份:2017
- 资助金额:
$ 160.03万 - 项目类别:
Wake Forest Translational Alcohol Research Center (WF-TARC)
维克森林转化酒精研究中心 (WF-TARC)
- 批准号:
10079833 - 财政年份:2017
- 资助金额:
$ 160.03万 - 项目类别:
Neural Substrates of Comorbid Alcohol Use Disorder and Post-Traumatic Stress Disorder
共病酒精使用障碍和创伤后应激障碍的神经基质
- 批准号:
9486289 - 财政年份:2017
- 资助金额:
$ 160.03万 - 项目类别:
2016 and 2018 Alcohol and the Nervous System GRC
2016 和 2018 酒精与神经系统 GRC
- 批准号:
9171365 - 财政年份:2015
- 资助金额:
$ 160.03万 - 项目类别:
Translational Studies on Early-life Stress and Vulnerability to Alcohol Addiction
早期生活压力和酒精成瘾脆弱性的转化研究
- 批准号:
8730268 - 财政年份:2012
- 资助金额:
$ 160.03万 - 项目类别:
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