Wake Forest Translational Alcohol Research Center (WF-TARC)

维克森林转化酒精研究中心 (WF-TARC)

• 批准号: 10079833
• 负责人: JEFFREY L WEINER
• 金额: $ 160.28万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-12-10 至 2022-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10079833
• 关键词: Adolescence; Adolescent; Alcohol consumption; Alcohol dependence; Alcoholism; Alcohols; Animal Model; Animals; Anxiety; Behavior; Biological; Biometry; Brain; Cessation of life; Childhood; Clinical; Communication; Communities; Data; Development; Diagnosis; Disease; Drug Addiction; Early Diagnosis; Ensure; Environment; Experimental Designs; Experimental Models; Faculty; Funding; Goals; Grant; Healthcare Systems; Human; Human Subject Research; Individual; Infrastructure; Institution; Interdisciplinary Study; Intervention; Investments; Lead; Leadership; Learning; Link; Methods; Modeling; Molecular; Monkeys; National Institute on Alcohol Abuse and Alcoholism; Neurobiology; Pilot Projects; Populations at Risk; Postdoctoral Fellow; Prevalence; Publishing; Relapse; Research; Research Design; Research Methodology; Research Personnel; Research Project Grants; Resistance; Resources; Risk; Rodent; Students; Substance Addiction; Talents; Therapeutic; Therapeutic Intervention; Training; Translational Research; Translations; United States; Vulnerable Populations; addiction; alcohol misuse; alcohol related problem; alcohol research; alcohol use disorder; behavioral study; cost; critical period; educational atmosphere; endophenotype; epidemiology study; evidence base; forest; human model; innovation; medical schools; multidisciplinary; neural circuit; neuroadaptation; neurobehavioral; next generation; nonhuman primate; novel; novel therapeutic intervention; problem drinker; programs; recruit; relating to nervous system; resilience; responsible alcohol use; socioeconomics; stressor; substance use; success; therapeutically effective; training opportunity

PROJECT SUMMARY The central goal of the Wake Forest Translational Alcohol Research Center (WF-TARC) is to employ animal models and human subjects research to study behavioral and neurobiological substrates associated with vulnerability (and resilience) to alcohol use disorder (AUD). This Center builds on a highly productive translational alcohol research program at WFSM that was recently established with NIAAA developmental program project (P01) support. The WF-TARC will have four research projects and two cores. An administrative core will provide the leadership and infrastructure needed to ensure integration across all research projects, provide biostatistical support, and promote interactions and communication between this Center and the many other addiction- related research and educational programs at Wake Forest School of Medicine (WFSM). A pilot project core will be established to advance the goals and objectives of the WF-TARC. This core will fund four projects each year to attract new investigators to bring their talent and expertise to the study of AUD vulnerability. The unifying research focus of the WF-TARC will be to leverage the strengths and advantages of animal models and human subjects research to study behavioral correlates of AUD vulnerability and identify neurobiological adaptations that contribute to this heightened risk of developing AUD. Studies will employ cutting-edge, multidisciplinary experimental approaches spanning molecular, cellular, circuit, and whole-brain analyses. Importantly, each project will evaluate novel interventions targeted at the reversing the maladaptive neural adaptations that promote AUD vulnerability. The highly-integrated conceptual framework and research design will facilitate backward and forward interactions between the projects, facilitating the rapid translation of therapeutic discoveries from animals to humans. The WF-TARC takes advantage of a well-established, extremely collaborative translational alcohol research program at WFSM and will benefit from a strong and growing institutional focus on alcohol and drug addiction research. This Center will further enhance the outstanding educational environment at our institution, providing unique training opportunities for the students and postdoctoral who will become the next generation of translational alcohol researchers. Finally, the innovative research that will be supported by the WF-TARC may lead to better evidence-based therapies for individuals who are at greatest risk of developing AUD, individuals who are particularly ill-served by current AUD treatment options.

项目总结 维克森林酒精转化研究中心(WF-TARC)的中心目标是利用动物 模型和人类受试者研究相关的行为和神经生物学底物 对酒精使用障碍(AUD)的脆弱性(和韧性)。该中心建立在高效的 WFSM最近与NIAAA Development共同建立的转化醇研究计划 计划项目(P01)支持。 WF-TARC将有四个研究项目和两个核心。管理核心将提供 确保整合所有研究项目所需的领导力和基础设施，提供生物统计学 支持并促进本中心与许多其他成瘾者之间的互动和沟通- 维克森林医学院(WFSM)的相关研究和教育项目。试点项目核心 将会被建立，以推进WF-TARC的目标和目的。这一核心将分别为四个项目提供资金 年，吸引新的调查人员将他们的才华和专业知识带到澳元脆弱性的研究中。 WF-TARC的统一研究重点将是利用动物的优势和优势 模型和人类受试者研究AUD脆弱性的行为相关性并确定 神经生物学适应导致发生AUD的风险增加。研究将采用 跨分子、细胞、电路和全脑的尖端、多学科实验方法 分析。重要的是，每个项目都将评估旨在扭转适应不良的新干预措施 促进AUD脆弱性的神经适应。高度整合的概念框架和研究 设计将促进项目之间的向前和向后交互，促进快速翻译 从动物到人类的治疗发现。 WF-TARC利用了一项成熟的、高度合作的转化醇研究 WFSM计划，并将受益于对酒精和药物成瘾的强有力和日益增长的机构关注 研究。该中心将进一步提升我校优秀的教育环境，提供 为学生和博士后提供独特的培训机会，他们将成为下一代 转化酒研究人员。最后，WF-TARC将支持的创新研究可能 为罹患AUD风险最高的个人带来更好的循证治疗 这些人尤其受到当前澳大利亚人糖尿病治疗选择的不利影响。