ERYTHROBLAST NUCLEAR EXTRUSION: MOLECULAR MECHANISMS

成红细胞核挤压：分子机制

• 批准号: 7722172
• 负责人: JOEL A CHASIS
• 金额: $ 3.53万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7722172
• 关键词: Cell Nucleus; Cell membrane; Computer Retrieval of Information on Scientific Projects Database; Derivation procedure; Erythroblasts; Erythropoiesis; Event; Funding; Goals; Grant; Institution; Membrane Proteins; Molecular; Nuclear; Organelles; Play; Research; Research Personnel; Resources; Reticulocytes; Role; Source; Staging; United States National Institutes of Health; Vesicle; tomography

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this project is to examine key aspects of erythropoiesis, specifically the latter stages of nuclear extrusion, using cryo x-ray tomography. This will enable us to examine key events, including the reorganization of nuclear substructures to prepare for extrusion, the derivation of vesicles that play a key role in providing the plasma membranes that will surround extruded nuclei and reticulocytes, and the partitioning of organelles and plasma membrane proteins between extruding nuclei and reticulocytes.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 这个项目的目标是研究红细胞生成的关键方面，特别是核挤出的后期阶段，使用冷冻X射线断层扫描。这将使我们能够检查关键事件，包括重组核亚结构，以准备挤出，衍生的囊泡，在提供质膜，将围绕挤出的细胞核和网织红细胞，和细胞器和质膜蛋白质之间的分区挤出核和网织红细胞发挥关键作用。