3D DETERMINATION OF AN NPASE PHOSPHODIESTERASE

NPASE 磷酸二酯酶的 3D 测定

• 批准号: 7721317
• 负责人: DEMETRIOS BRADDOCK
• 金额: $ 0.35万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7721317
• 关键词: Biochemistry; Biological Process; Cell surface; Computer Retrieval of Information on Scientific Projects Database; Enzymes; Eukaryota; Eukaryotic Cell; Evolution; Funding; Grant; Hydrolysis; Institution; Integral Membrane Protein; Phosphoric Monoester Hydrolases; Research; Research Personnel; Resources; Source; United States National Institutes of Health; enzyme activity; extracellular; improved; inorganic phosphate; member; phosphoric diester hydrolase

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. NPPs are members of the AP (Alkalyne Phosphatase) superfamily. They catalyse the phosphate diester hydrolysis. In eukaryotes, these enzymes are found at cell surfaces, either as transmembrane proteins or secreted ,and hydrolyse extracellular phosphate diesters to afect a variety of biological processes (Jesse G.Zalatan et al., Biochemistry, 2006). The structural study of NPPs will allow to improve our understanding of enzymes catalytic mechanisms and the evolution of new enzyme activities.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 NPP是AP（碱性磷酸酶）超家族的成员。它们催化磷酸二酯水解。 在真核生物中，这些酶作为跨膜蛋白或分泌的存在于细胞表面，并且水解细胞外磷酸二酯以影响多种生物过程（Jesse G.Zalatan et al. Biochemistry，2006）。NPPs的结构研究将有助于我们更好地理解酶的催化机制和新酶活性的进化。