3D DETERMINATION OF AN NPASE PHOSPHODIESTERASE

NPASE 磷酸二酯酶的 3D 测定

• 批准号: 8171514
• 负责人: DEMETRIOS BRADDOCK
• 金额: $ 0.71万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8171514
• 关键词: Biochemistry; Biological Process; Cell surface; Computer Retrieval of Information on Scientific Projects Database; Enzymes; Eukaryota; Evolution; Funding; Grant; Hydrolysis; Institution; Integral Membrane Protein; Phosphoric Monoester Hydrolases; Research; Research Personnel; Resources; Source; United States National Institutes of Health; enzyme activity; extracellular; improved; inorganic phosphate; member; phosphoric diester hydrolase

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. NPPs are members of the AP (Alkalyne Phosphatase) superfamily. They catalyse the phosphate diester hydrolysis. In eukaryotes, these enzymes are found at cell surfaces, either as transmembrane proteins or secreted ,and hydrolyse extracellular phosphate diesters to afect a variety of biological processes (Jesse G.Zalatan et al., Biochemistry, 2006). The structural study of NPPs will allow to improve our understanding of enzymes catalytic mechanisms and the evolution of new enzyme activities

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 NPP是AP（烯烃磷酸酶）超家族的成员。它们催化磷酸盐二酯的水解。 在真核生物中，这些酶是在细胞表面上发现的，要么是跨膜蛋白或分泌的，而且水解细胞外磷酸盐二甲体以影响各种生物学过程（Jesse G.Zalatan等人，生物化学，2006年）。 NPP的结构研究将使我们对酶催化机制的理解和新酶活性的发展