3D DETERMINATION OF AN NPASE PHOSPHODIESTERASE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 NPP是碱性磷酸酶超家族的成员。它们催化磷酸二酯的水解。在真核生物中，这些酶以跨膜蛋白或分泌物的形式存在于细胞表面，并能水解胞外磷酸二酯以影响各种生物过程(Jesse G.Zalatan等人，生物化学，2006)。NPPs的结构研究将有助于我们更好地理解酶的催化机制和新的酶活性的进化

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. NPPs are members of the AP (Alkalyne Phosphatase) superfamily. They catalyse the phosphate diester hydrolysis. In eukaryotes, these enzymes are found at cell surfaces, either as transmembrane proteins or secreted ,and hydrolyse extracellular phosphate diesters to afect a variety of biological processes (Jesse G.Zalatan et al., Biochemistry, 2006). The structural study of NPPs will allow to improve our understanding of enzymes catalytic mechanisms and the evolution of new enzyme activities