PROFILING OF CORTICAL AREAS BY MICRO-MRI

通过显微 MRI 分析皮质区域

• 批准号: 7726197
• 负责人: Jacopo Annese
• 金额: $ 0.65万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-01 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7726197
• 关键词: Area; Brain; Computer Retrieval of Information on Scientific Projects Database; Data; Funding; Goals; Grant; Human; Image; Individual; Institution; Magnetic Resonance Imaging; Maps; Microscopic; Relative (related person); Research; Research Personnel; Resources; Sampling; Scanning; Scheme; Source; Specimen; Surface; Thick; United States National Institutes of Health

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of the study is to analyze the cortical mantle of the human brain systematically, according to Brodmann's parcellation scheme, in order to determine the microscopic MRI profiles of individual cortical areas. Small samples of cortex, acquired perpendicular to the cortical surface, will be imaged using established sequences available for the 9T magnet at Duke's CIVM. Micro-MRI signatures relative to specific architetconic features in each sample (layer thickness and cytological parameters) will be validated by subsequent quantitative histological analysis. Imaging data and quantitative information will be displayed onto an organized surface map of the cortex, derived from the scan of the whole original brain specimen.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 这项研究的目的是系统地分析人脑的皮质地幔，根据Brodmann的parcellation计划，以确定个别皮质区的显微MRI轮廓。在杜克的CIVM中，将使用可用于9 T磁体的既定序列对垂直于皮质表面采集的皮质小样本进行成像。与每个样本中特定结构特征（层厚度和细胞学参数）相关的微型MRI特征将通过后续的定量组织学分析进行验证。成像数据和定量信息将显示在一个有组织的表面地图的皮层，从整个原始大脑标本的扫描。