PROFILING OF CORTICAL AREAS BY MICRO-MRI

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究的目的是根据Brodmann的分割方案，系统地分析人脑的皮质外套层，以确定单个皮质区域的显微MRI轮廓。与皮质表面垂直获取的小样本皮质，将使用杜克大学CIVM的9T磁铁可用的既定序列进行成像。随后的定量组织学分析将验证每个样本中与特定结构圆锥特征(层厚度和细胞学参数)相关的Micro MRI签名。成像数据和定量信息将显示在大脑皮质的有组织的表面地图上，该地图来自对整个原始大脑样本的扫描。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of the study is to analyze the cortical mantle of the human brain systematically, according to Brodmann's parcellation scheme, in order to determine the microscopic MRI profiles of individual cortical areas. Small samples of cortex, acquired perpendicular to the cortical surface, will be imaged using established sequences available for the 9T magnet at Duke's CIVM. Micro-MRI signatures relative to specific architetconic features in each sample (layer thickness and cytological parameters) will be validated by subsequent quantitative histological analysis. Imaging data and quantitative information will be displayed onto an organized surface map of the cortex, derived from the scan of the whole original brain specimen.