MENDELIAN RANDOMIZATION TO INFER CAUSATION IN OBSERVATIONAL EPIDEMIOLOGY

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Currently, little is known about the mechanisms that distort the distribution of alleles from that expected from Mendel's first law between gamete formation, conception, birth and entry into a study. It is therefore difficult to estimate the extent to which these mechanisms may affect the results of Mendelian randomization studies. However, these mechanisms should not be assumed to be negligible until they have been properly evaluated. Potential for segregation distortion, selective survival and parent-of-origin effect should be kept in mind when conducting Mendelian randomization studies to draw causal inference in observational studies.