STUDIES OF THE METABOLIC SYNDROME

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 我们研究了血浆醛固酮和血浆肾素活性与代谢综合征及其各组分的关系。 我们分析了来自塞舌尔的一项基于家庭的研究的数据，该研究由来自69个非洲裔家庭的356名参与者（160名男性和196名女性）组成。 在多变量模型中，血浆醛固酮与老年人血压有显著性差异（P<0.05）（与年龄的相互作用，P<0.05）和男性腰围与高密度脂蛋白胆固醇呈负相关，尤其是在尿钾排泄量升高的个体中（与尿钾相互作用，P<0.05）;血浆肾素活性与甘油三酯和空腹血糖显著相关。 血浆醛固酮，而不是血浆肾素活性，与代谢综合征本身相关，独立于与其单独成分的关联。 血浆肾素活性与代谢综合征的某些组分相关，而血浆醛固酮与代谢综合征的其他组分相关，这一观察结果提示了不同的潜在机制。 这些研究结果加强了以前的观察表明，醛固酮与几个心血管危险因素，也表明，醛固酮可能有助于增加心血管疾病的风险在非洲裔代谢综合征的个人。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We investigated the associations of plasma aldosterone and plasma renin activity with the metabolic syndrome and each of its components. We analyzed data from a family based study in the Seychelles made up of 356 participants (160 men and 196 women) from 69 families of African descent. In multivariable models, plasma aldosterone was associated positively (P<0.05) with blood pressure in older individuals (interaction with age, P<0.05) and with waist circumference with men (interaction with sex, P<0.05) and negatively with high-density lipoprotein cholesterol, in particular in individuals with elevated urinary potassium excretion (interaction with urinary potassium, P<0.05); plasma renin activity was significantly associated with triglycerides and fasting blood glucose. Plasma aldosterone, but not plasma renin activity, was associated with the metabolic syndrome per se, independently of the association with its separate compenents. The observation that plasma renin activity was associated with some components of the metabolic syndrome, whereas plasma aldosterone was associated with other components of the metabolic syndrome, suggests different underlying mechanisms. These findings reinforce previous observations suggesting that aldosterone is associated with several cardiovascular risk factors and also suggest that aldosterone might contribute to the increased cardiovascular disease risk in individuals of African descent with the metabolic syndrome.