TWO-PHOTON FLUORESCENCE IMAGING OF UV EFFECTS UPON THE SKIN

紫外线对皮肤影响的双光子荧光成像

• 批准号: 7724073
• 负责人: KERRY M HANSON
• 金额: $ 1.01万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7724073
• 关键词: Actinic keratosis; Antioxidants; Computer Retrieval of Information on Scientific Projects Database; Depth; Epidermis; Funding; Grant; Institution; Molecular; Numbers; Oxygen; Reactive Oxygen Species; Research; Research Personnel; Resources; Skin; Skin Aging; Skin Cancer; Source; Surface; United States National Institutes of Health; fluorescence imaging; interest; two-photon

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We are looking to see if antioxidants decrease the level of reactive oxygen species (ROS) generated in the skin by UV. ROS are highly reactive derivatives of molecular oxygen, and are associated with actinic keratosis, photoaging and skin cancer. We are interested to see if antioxidants applied to the skin surface can reduce the number of ROS that are generated deeper in the epidermis.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 我们正在研究抗氧化剂是否能降低紫外线在皮肤中产生的活性氧（ROS）水平。 ROS是分子氧的高度反应性衍生物，并且与光化性角化病、光老化和皮肤癌相关。 我们有兴趣看看应用于皮肤表面的抗氧化剂是否可以减少表皮深层产生的ROS数量。