TWO-PHOTON FLUORESCENCE IMAGING OF UV EFFECTS UPON THE SKIN

紫外线对皮肤影响的双光子荧光成像

• 批准号: 8365753
• 负责人: KERRY M HANSON
• 金额: $ 4.32万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-20 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8365753
• 关键词: Actinic keratosis; Antioxidants; Epidermis; Fluorescence; Funding; Grant; Laboratories; Molecular; National Center for Research Resources; Oxygen; Principal Investigator; Reactive Oxygen Species; Research; Research Infrastructure; Resources; Skin; Skin Cancer; Source; Surface; United States National Institutes of Health; cost; fluorescence imaging; interest; two-photon

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. We are looking to see if antioxidants decrease the level of reactive oxygen species (ROS) generated in the skin by UV. ROS are highly reactive derivatives of molecular oxygen, and are associated with actinic keratosis, photoaging and skin cancer. We are interested to see if antioxidants applied to the skin surface can reduce the number of ROS that are generated deeper in the epidermis.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 子项目的主要研究者可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 我们正在研究抗氧化剂是否能降低紫外线在皮肤中产生的活性氧（ROS）水平。 ROS是分子氧的高度反应性衍生物，并且与光化性角化病、光老化和皮肤癌相关。 我们有兴趣看看应用于皮肤表面的抗氧化剂是否可以减少表皮深层产生的ROS数量。