TWO-PHOTON FLUORESCENCE IMAGING OF UV EFFECTS UPON THE SKIN

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 我们正在研究抗氧化剂是否会降低紫外线在皮肤中产生的活性氧物种(ROS)的水平。ROS是分子氧的高活性衍生物，与光化性角化病、光老化和皮肤癌有关。我们感兴趣的是，将抗氧化剂应用于皮肤表面是否可以减少表皮深处产生的ROS数量。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We are looking to see if antioxidants decrease the level of reactive oxygen species (ROS) generated in the skin by UV. ROS are highly reactive derivatives of molecular oxygen, and are associated with actinic keratosis, photoaging and skin cancer. We are interested to see if antioxidants applied to the skin surface can reduce the number of ROS that are generated deeper in the epidermis.