TWO-PHOTON FLUORESCENCE IMAGING OF UV EFFECTS UPON THE SKIN

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 研究中心，而研究中心不一定是研究者所在的机构。 我们正在研究抗氧化剂是否能降低紫外线在皮肤中产生的活性氧（ROS）水平。 ROS是分子氧的高度反应性衍生物，并且与光化性角化病、光老化和皮肤癌相关。 我们有兴趣看看应用于皮肤表面的抗氧化剂是否可以减少表皮深层产生的ROS数量。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We are looking to see if antioxidants decrease the level of reactive oxygen species (ROS) generated in the skin by UV. ROS are highly reactive derivatives of molecular oxygen, and are associated with actinic keratosis, photoaging and skin cancer. We are interested to see if antioxidants applied to the skin surface can reduce the number of ROS that are generated deeper in the epidermis.