INVESTIGATIONS OF ALPHA-SYNUCLEIN IN PARKINSONIAN PATHOGENESIS

α-突触核蛋白在帕金森病发病机制中的研究

• 批准号: 7722442
• 负责人: JULIA B GEORGE
• 金额: $ 2.93万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7722442
• 关键词: Collaborations; Computer Retrieval of Information on Scientific Projects Database; Electrons; Funding; Goals; Grant; Hydroxybutyrates; Institution; Investigation; Label; Life; Microscopic; Oxidoreductase; Parkinson Disease; Parkinsonian Disorders; Pathogenesis; Research; Research Personnel; Resolution; Resources; Role; Source; System; Techniques; Therapeutic; Three-Dimensional Image; Three-Dimensional Imaging; United States National Institutes of Health; Work; alpha synuclein; improved; intracellular protein transport; protein transport; reconstruction

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Our goals in this collaboration are to investigate the role of alpha-synuclein and hydroxybutyrate dehydrogenase type 2 (BDH2) in the progression of Parkinson disease (PD) and assess putative therapeutic strategies. We intend to apply the tetracysteine (4Cys)-labeling system developed at NCMIR to track, at multiple resolution scales, the trafficking of proteins associated with PD. This work will draw upon the techniques being advanced at NCMIR, including improved 4Cys approaches, correlated live imaging-3D electron microscopic analysis, and high-resolution electron tomographic reconstruction.

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