3-D ORGANIZATION OF GENE EXPRESSION

基因表达的 3D 组织

• 批准号: 7722404
• 负责人: DAVID L SPECTOR
• 金额: $ 1.56万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7722404
• 关键词: 3-Dimensional; Chromatin Structure; Collaborations; Computer Retrieval of Information on Scientific Projects Database; Electron Microscope; Funding; Gene Expression; Genetic Transcription; Goals; Grant; Image; Institution; Life; Morphology; Nucleoplasm; Research; Research Personnel; Resources; Site; Source; System; Techniques; Transcriptional Activation; United States National Institutes of Health; messenger ribonucleoprotein; tomography

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Our goal is to investigate the chromatin structure during activation of transcription and to examine mRNP morphology at the transcription site and in the nucleoplasm using tetracysteine-biarsenical probes, correlated live imaging, and electron microscope tomography. The application and adaptation of these techniques to our system will be developed in collaboration with NCMIR/UCSD.

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