IN VIVO CHARACTERIZATION OF RNA VIRUS ASSEMBLY LINES WITH EM TOMOGRAPH

使用电子断层扫描仪对 RNA 病毒组装线进行体内表征

• 批准号: 7722458
• 负责人: Jason Kenneth Lanman
• 金额: $ 1.17万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7722458
• 关键词: Computer Retrieval of Information on Scientific Projects Database; Electron Microscope; Facilities and Administrative Costs; Funding; Future; Grant; Human; Influenza; Institution; RNA Viruses; Research; Research Personnel; Resources; Societies; Source; United States; United States National Institutes of Health; Vaccines; Viral; Virus; Virus Assembly; cost; human disease; in vivo; novel; pandemic disease; pathogen; tomography

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Viruses are the cause of many human diseases through out the world, and result in major financial losses to society. In the United States Influenza, a human pathogen, is responsible for an estimated total direct and indirect cost of $10 billion per year, and the costs of a serious future pandemic could cost hundreds of billions of dollars. Investigating virus assembly and entry will help researchers develop novel anti-viral targets and vaccines. The focus of this proposal is to use to electron microscope tomography to answer key questions about RNA virus lifecycle in vivo.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 病毒是世界各地许多人类疾病的原因，并导致社会造成重大财务损失。在美国，人类病原体，估计的直接和间接成本为每年100亿美元，而严重的未来大流行的成本可能需要数亿美元。研究病毒组装和进入将有助于研究人员开发新的抗病毒靶标和疫苗。该建议的重点是用于电子显微镜断层扫描，以回答有关体内RNA病毒生命周期的关键问题。