MULTISCALE CHARACTERIZATION OF VIRAL VECTOR-INDUCED GLIOBLASTOMAS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 本项目的目的是在多形性胶质母细胞瘤(GBM)小鼠模型中研究伴随肿瘤形成的分子事件。一些感兴趣的目标包括血管生成标记物、细胞增殖指示物和细胞特异性标记物，以跟踪特定细胞群体的区域变化。我们将使用NCMIR开创和完善的技术组合来研究这些靶点在GBM进展过程中的分布和动态行为，包括大规模测绘和相关的光学和电子显微镜成像，以跟踪神经胶质细胞的精细过程以及这些细胞在受影响的脑区增殖时的相关细胞和分子相互作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this project is to investigate the molecular events accompanying formation of tumors in a mouse model of glioblastoma multiforme (GBM). Some targets of interest include angiogenic markers, indicators of cell proliferation, and cell specific markers to track regional changes in specific cell populations. We will investigate the distribution and dynamic behavior of these targets during GBM progression using a combination of techniques being pioneered and refined at NCMIR ¿¿ including large-scale mapping and correlated light and electron microscopic imaging to follow the fine processes of glial cells and associated cellular and molecular interactions as these cells proliferate in the affected brain regions.