PATHWAYS LINKING REDUCED SLEEP DURATION AND QUALITY TO OBESITY RISK

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Our overall goal is to obtain causative evidence linking short sleep or reduced sleep quality, to alterations in specific central nervous system and peripheral pathways regulating energy intake. Normal young adults will be studied under three carefully controlled laboratory conditions with 4 days with undisturbed sleep (8.5hrs in bed; "baseline"), 4 days with short undisturbed sleep (4.5 hrs in bed; "short sleep") and 4 days of experimental suppression of SWS (8.5 hrs in bed; "SWS sleep suppression"). Both the "short sleep" and "SWS suppression" conditions will be followed by 2 nights of undisturbed recovery sleep with 9 hours in bed.