Technology-Supported Treatment of Sleep Apnea in Prediabetes
糖尿病前期睡眠呼吸暂停的技术支持治疗
基本信息
- 批准号:10886362
- 负责人:
- 金额:$ 28万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-08-01 至 2024-07-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAdherenceAdvisory CommitteesBeta CellBlood PressureCardiometabolic DiseaseCardiovascular systemCaringCell physiologyClinical TrialsContinuous Positive Airway PressureDiabetes MellitusDiagnosisDiseaseEnvironmentFeedbackGlucoseGoalsHigh PrevalenceIncidenceIndividualInterventionKnowledgeLevel of EvidenceLife StyleLife Style ModificationMetabolicMonitorOutcomeOverweightParentsPatientsPersonsPrediabetes syndromePreventive Health ServicesRandomizedRandomized, Controlled TrialsRecommendationSleep Apnea SyndromesSpecialistTechnologyTestingTimeadult obesityblood lipidcardiometabolic riskcardiometabolismclinical decision-makingclinically relevantcost effectivediet and exerciseevidence baseglucose metabolismhigh risk populationimprovedinsulin sensitivitylifestyle interventionnovelpreventrandomized, clinical trialsroutine screeningscreeningstandard of caresuccess
项目摘要
PROJECT SUMMARY (from parent trial)
Intensive lifestyle interventions (diet and exercise) are the mainstay of treatment in prediabetes. Despite their
efficacy, diabetes incidence is rising, and thus there is a critical need for additional strategies to prevent diabetes
and to reduce its cardiovascular complications. Sleep apnea is a treatable disorder that has been strongly
associated with cardiometabolic disease. Continuous positive airway pressure (CPAP) is the recommended
treatment for those who are diagnosed with sleep apnea. However, about 80% of patients who have sleep apnea
remain undiagnosed, and thus not receive CPAP treatment. To date, not a single clinical trial investigating the
effects of lifestyle interventions on cardiometabolic risk in prediabetes assessed for sleep apnea or included an
intervention to treat sleep apnea. Despite high prevalence of sleep apnea in prediabetes, the vast majority of
patients are not diagnosed due to lack of high level evidence to indicate that treatment specifically improves
diabetes and cardiovascular outcomes, which are the primary treatment objectives of specialists caring for this
high-risk population. Moreover, due to insufficient evidence from rigorous and well-powered randomized
controlled trials, the U.S. Preventive Health Services Task Force recommended against general screening for
sleep apnea. Notably, not a single randomized controlled CPAP trial assessing cardiometabolic outcomes
utilized a technology-supported intervention to promote adherence, a key limitation in prior studies. Our proposed
randomized clinical trial will fill these critical knowledge gaps and address a focused, novel and clinically relevant
question. We will determine, for the first time, whether adding CPAP treatment to a lifestyle intervention improves
cardiometabolic outcomes beyond that achieved with lifestyle alone (i.e. current standard of care) in prediabetes.
Overweight and obese adults who have prediabetes and sleep apnea will be randomly assigned to lifestyle alone
or lifestyle plus CPAP. We will obtain the same metabolic and cardiovascular assessments at baseline and after
6-months of intervention. Our specific aims are to test the hypothesis that a combined intervention (lifestyle plus
CPAP) will lead to greater improvements in glucose levels, insulin sensitivity and beta cell function (Aim 1), and
blood pressure and lipid profile (Aim2), as compared to lifestyle alone. To maximize intervention success and
minimize subject burden, we propose a highly efficient, cost effective technology-supported approach for lifestyle
intervention and CPAP treatment, which will allow real-time, objective monitoring of individuals in their habitual
environment and delivering timely feedback to attain goals. To date, no prior study has implemented such a
technology-supported intervention in people with prediabetes and sleep apnea. An added benefit of CPAP on
cardiometabolic outcomes will strongly support routine screening for and treatment of sleep apnea in prediabetes
and will encourage those prescribing CPAP to routinely implement intensive lifestyle modifications as part of
treatment package for sleep apnea. Our trial will address a major gap in randomized clinical trials on the impact
of sleep apnea treatment on glucose metabolism, and thus inform evidence-based clinical decision making.
项目总结(来自家长试验)
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Esra Tasali其他文献
Esra Tasali的其他文献
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{{ truncateString('Esra Tasali', 18)}}的其他基金
Sleep Extension: A Novel Intervention for Weight Loss in Young Adults
延长睡眠:年轻人减肥的新干预措施
- 批准号:
10753226 - 财政年份:2023
- 资助金额:
$ 28万 - 项目类别:
Technology-Supported Treatment of Sleep Apnea in Prediabetes
糖尿病前期睡眠呼吸暂停的技术支持治疗
- 批准号:
9762470 - 财政年份:2019
- 资助金额:
$ 28万 - 项目类别:
Mechanisms of Prediabetic States in Obstructive Sleep Apnea
阻塞性睡眠呼吸暂停的糖尿病前期状态机制
- 批准号:
10222768 - 财政年份:2019
- 资助金额:
$ 28万 - 项目类别:
Mechanisms of Prediabetic States in Obstructive Sleep Apnea
阻塞性睡眠呼吸暂停的糖尿病前期状态机制
- 批准号:
10439458 - 财政年份:2019
- 资助金额:
$ 28万 - 项目类别:
Technology-Supported Treatment of Sleep Apnea in Prediabetes
糖尿病前期睡眠呼吸暂停的技术支持治疗
- 批准号:
10226277 - 财政年份:2019
- 资助金额:
$ 28万 - 项目类别:
Mechanisms of Prediabetic States in Obstructive Sleep Apnea
阻塞性睡眠呼吸暂停的糖尿病前期状态机制
- 批准号:
9973169 - 财政年份:2019
- 资助金额:
$ 28万 - 项目类别:
Technology-Supported Treatment of Sleep Apnea in Prediabetes
糖尿病前期睡眠呼吸暂停的技术支持治疗
- 批准号:
10677837 - 财政年份:2019
- 资助金额:
$ 28万 - 项目类别:
Technology-Supported Treatment of Sleep Apnea in Prediabetes
糖尿病前期睡眠呼吸暂停的技术支持治疗
- 批准号:
10459449 - 财政年份:2019
- 资助金额:
$ 28万 - 项目类别:
Technology-Supported Treatment of Sleep Apnea in Prediabetes
糖尿病前期睡眠呼吸暂停的技术支持治疗
- 批准号:
9980894 - 财政年份:2019
- 资助金额:
$ 28万 - 项目类别:
Mechanisms of Prediabetic States in Obstructive Sleep Apnea
阻塞性睡眠呼吸暂停的糖尿病前期状态机制
- 批准号:
10674545 - 财政年份:2019
- 资助金额:
$ 28万 - 项目类别:
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