STRUCTURAL STUDIES OF PROTEINS FROM HYPERTHERMOHILIC VIRUSES

高温病毒蛋白质的结构研究

• 批准号: 7721260
• 负责人: CHARLES MARTIN LAWRENCE
• 金额: $ 0.7万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-15 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7721260
• 关键词: Blast Cell; Computer Retrieval of Information on Scientific Projects Database; Funding; Grant; Homologous Gene; Institution; Proteins; Research; Research Personnel; Resources; Source; Structure; United States National Institutes of Health; Viral Proteins; Virus; Work; beamline; protein function; protein structure

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Work at the NE-CAT beamline was focused on determining the structure of the STIV viral protein B129. The function of this protein can not be determined by sequence similarity using BLAST searches, or by CD searches or threading. We anticipate, however, that the structure of the protein will allow us to identify structural homologs, and thus to formulate a testable hypothesis regarding its function.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 NE-CAT光束线的工作重点是确定STIV病毒蛋白B129的结构。 该蛋白的功能不能通过使用BLAST搜索的序列相似性或通过CD搜索或穿线来确定。 然而，我们预计，蛋白质的结构将使我们能够识别结构同源物，从而制定一个关于其功能的可验证的假设。