STRUCTURAL STUDIES OF IRON TRANSPORT AND HOMEOSTASIS AND OF ARCHAEAL VIRUSES

铁运输和体内平衡以及古细菌病毒的结构研究

基本信息

  • 批准号:
    8170298
  • 负责人:
  • 金额:
    $ 0.03万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2010
  • 资助国家:
    美国
  • 起止时间:
    2010-05-01 至 2011-02-28
  • 项目状态:
    已结题

项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. On one hand, more than 1 BILLION people world-wide suffer from anemia. On the other, hereditary hemochromatosis is the most prevalent autosomal recessive disease known with a carrier frequency of approximately 1 in 10, in people of northern European extraction. Many other diseases of iron overload are known, often leading to death by age 50. We are engaged in structural studies of a number of proteins involved in human iron transport, including the transferrin receptor (TfR) and the Steap family of ferrireductases. In a different vein, recent work also shows that the transferrin receptor is a target for gambogic acid, which triggers apoptosis. Thus, we are also working towards the structure of TfR in complex with a more soluble gambogic acid analogue. Finally, we are also studying bacterial and archaeal DPSL proteins, a newly identified member of the ferritin superfamily that contain a defining ?thioferritin motif?. These proteins are present in the most common anaerobic human pathogens, Bacteroides fragilis and Bacteroides thetaiotaomicron. A second project focuses on structural studies of Archaeal viruses. More than 5,000 viruses and phage are known that infect bacteria and the eukaryotes, however, less than 35 Archaeal viruses have been identified, primarily because people are just beginning to look for them. The first hyperthermophilic crenarchaeal viral genomes have now been sequenced, and they generally show a lack of homology with the public databases. Thus it is difficult to assign function to these viral genes without direct biochemical and genetic studies. We are thus engaged in a ?function from structure? project that focuses on two families of hyperthermophilic crenarchaeal viruses. We have now solved structures for 13 crenarchaeal viral proteins. These studies are providing a significant insight into the life cycles of viruses from this third branch in the tree of life and are expected to provide a window onto many of the fundamental biochemical processes of their crenarchaeal hosts.
这个子项目是众多研究子项目之一

项目成果

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CHARLES MARTIN LAWRENCE其他文献

CHARLES MARTIN LAWRENCE的其他文献

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{{ truncateString('CHARLES MARTIN LAWRENCE', 18)}}的其他基金

A Genetically Encoded Phosphorescent, Electron Dense Probe for Correlative Light and Electron Microscopy
用于相关光和电子显微镜的基因编码磷光电子致密探针
  • 批准号:
    10547694
  • 财政年份:
    2022
  • 资助金额:
    $ 0.03万
  • 项目类别:
STRUCTURAL STUDIES OF IRON TRANSPORT AND HOMEOSTASIS AND OF ARCHAEAL VIRUSES
铁运输和体内平衡以及古细菌病毒的结构研究
  • 批准号:
    8362297
  • 财政年份:
    2011
  • 资助金额:
    $ 0.03万
  • 项目类别:
STRUCTURAL STUDIES OF IRON TRANSPORT AND HOMEOSTASIS AND OF ARCHAEAL VIRUSES
铁运输和体内平衡以及古细菌病毒的结构研究
  • 批准号:
    8170096
  • 财政年份:
    2010
  • 资助金额:
    $ 0.03万
  • 项目类别:
Structural and Functional Studies of Iron Transport and Homeostasis
铁转运和稳态的结构和功能研究
  • 批准号:
    8312564
  • 财政年份:
    2009
  • 资助金额:
    $ 0.03万
  • 项目类别:
Structural and Functional Studies of Iron Transport and Homeostasis
铁转运和稳态的结构和功能研究
  • 批准号:
    7895548
  • 财政年份:
    2009
  • 资助金额:
    $ 0.03万
  • 项目类别:
STRUCTURAL STUDIES OF IRON TRANSPORT AND HOMEOSTASIS AND OF ARCHAEAL VIRUSES
铁运输和体内平衡以及古细菌病毒的结构研究
  • 批准号:
    7954423
  • 财政年份:
    2009
  • 资助金额:
    $ 0.03万
  • 项目类别:
Structural and Functional Studies of Iron Transport and Homeostasis
铁转运和稳态的结构和功能研究
  • 批准号:
    8139020
  • 财政年份:
    2009
  • 资助金额:
    $ 0.03万
  • 项目类别:
STRUCTURAL STUDIES OF IRON TRANSPORT AND HOMEOSTASIS AND OF ARCHAEAL VIRUSES
铁运输和体内平衡以及古细菌病毒的结构研究
  • 批准号:
    7722114
  • 财政年份:
    2008
  • 资助金额:
    $ 0.03万
  • 项目类别:
STRUCTURAL STUDIES OF PROTEINS FROM HYPERTHERMOHILIC VIRUSES
高温病毒蛋白质的结构研究
  • 批准号:
    7721260
  • 财政年份:
    2008
  • 资助金额:
    $ 0.03万
  • 项目类别:
STUDIES OF IRON TRANSPORT AND HOMEOSTASIS; STUDIES OF ARCHAEAL VIRUS
铁运输和体内平衡的研究;
  • 批准号:
    7598073
  • 财政年份:
    2007
  • 资助金额:
    $ 0.03万
  • 项目类别:

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