Research Programs-Molecular Virology

研究项目-分子病毒学

• 批准号: 7513246
• 负责人: Daniel C. Dimaio
• 金额: $ 2.16万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-09 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7513246
• 关键词: Animal Viruses; Area; Award; Basic Science; Biological Phenomena; Direct Costs; Doctor of Medicine; Doctor of Philosophy; Faculty; Funding; Goals; Grant; HIV; Human; Immunology; Institute of Medicine (U.S.); Investigation; Laboratories; Lead; Leadership; Malignant Neoplasms; Mission; Molecular; Molecular Biology; Molecular Virology; Oncogenic Viruses; Oncology Group; Oncolytic; Oncolytic viruses; Paper; Papillomavirus; Peer Review; Play; Principal Investigator; Program Research Project Grants; Publishing; Research; Resource Sharing; Role; Training; United States National Academy of Sciences; United States National Institutes of Health; Vaccination; Vaccines; Viral; Virus; Virus Replication; base; cancer prevention; cost; improved; interest; member; metaplastic cell transformation; novel; novel strategies; post-doctoral training; pre-doctoral; prevent; programs; therapy development; tumor; tumorigenesis; vaccine development; virology

The Molecular Virology Basic Research Program (MVBRP) is an interdisciplinary basic research Program consisting of 17 independent but interactive laboratories with common interests in the molecular biology and immunology of viruses relevant to cancer and related topics. The overall goal of this Program is to facilitate research into the basic mechanisms of viral tumorigenesis and viral immunology; to conduct investigations that may lead to novel approaches to prevent or treat tumors associated with viruses; or to use viruses themselves as vaccines or oncolytic agents. Under the leadership of Daniel DiMaio, M.D., Ph.D., a tumor virologist who focuses on papillomaviruses, the MVBRP accomplishes these goals primarily by sponsoring the Molecular Virology and Oncology Group Meetings and the Steven Degar Memorial Lectureship, by encouraging and stimulating collaborative research, and by providing access to YCC funds and shared resources. Dr. DiMaio, along with other Program faculty, directs the graduate level course, The Molecular Biology of Animal Viruses. He is also the Principal Investigator of the NCI-funded Program Project Grant, Molecular Basis of Viral and Cellular Transformation, as well as an NCI-funded postdoctoral training grant in tumor virology and an NIAID-funded predoctoral training grant in virology. The distinguished faculty of this Program includes members of the National Academy of Sciences (Steitz) and the Institute of Medicine (Miller and Steitz). In aggregate, the Program members have received seven NIH MERIT Awards. There are now substantial efforts in the areas of basic tumor virology, vaccine development and viral immunology, and oncolytic viruses. In the last grant period, members of this Program published 243 cancer related papers, of which 4.1% were intra-programmatic and 18% inter-programmatic. Because viruses play a causal role in a substantial fraction of human tumors, studies carried out in this Program may eventually have an important impact on cancer prevention and treatment by revealing the mechanisms responsible for viral replication and tumorigenesis, thus identifying novel targets for translational efforts. In addition, these studies will reveal the mechanistic basis of biological phenomena that are relevant to the development and treatment of many cancers, including those not associated with viruses. The Molecular Virology Program currently has 18 members from 12 departments, with total research funding of $7.2 million direct costs ($10.6 million total costs), of which $6.3 million direct costs is peer-reviewed and $2.7 million direct costs is NCI-funded.

分子病毒学基础研究计划（MVBRP）是一个跨学科的基础研究计划 由17个独立但互动的实验室组成，这些实验室对分子生物学有共同的兴趣， 与癌症及相关主题相关的病毒免疫学。该计划的总体目标是促进 研究病毒致瘤和病毒免疫学的基本机制;进行调查 这可能会导致新的方法来预防或治疗与病毒有关的肿瘤;或者使用病毒 本身作为疫苗或溶瘤剂。在医学博士丹尼尔·迪马约的领导下，哲学博士、肿瘤 作为一名专注于乳头瘤病毒的病毒学家，MVBRP主要通过赞助 分子病毒学和肿瘤学小组会议和史蒂文·德加纪念讲座，由 鼓励和激励合作研究，并通过提供获得YCC资金和共享 资源DiMaio博士，沿着其他计划教师，指导研究生水平的课程，分子 动物病毒生物学他还是NCI资助的项目项目补助金的首席研究员， 病毒和细胞转化的分子基础，以及NCI资助的博士后培训补助金， 肿瘤病毒学和NIAID资助的病毒学博士前培训补助金。这方面杰出的能力 该计划包括国家科学院（Steitz）和医学研究所（米勒）的成员 Steitz）。该计划的成员总共获得了七项NIH MERIT奖。现在有 在基础肿瘤病毒学、疫苗开发和病毒免疫学领域做出了巨大努力， 溶瘤病毒在上一个资助期内，该项目的成员发表了243篇与癌症相关的论文， 其中4.1%为方案内，18%为方案间。因为病毒在一个 人类肿瘤的相当大的一部分，在这个计划中进行的研究可能最终有一个重要的 通过揭示病毒复制的机制对癌症预防和治疗的影响， 肿瘤发生，从而确定新的目标翻译的努力。此外，这些研究将揭示 生物现象的机械基础，与许多疾病的发展和治疗有关。 癌症，包括与病毒无关的癌症。分子病毒学项目目前有18个 来自12个部门的成员，研究经费总额为720万美元，直接费用总额为1060万美元 其中630万美元的直接费用是同行审查的，270万美元的直接费用是国家信息中心供资的。