GENOME SCIENCES

基因组科学组为研究人员提供了多种互补的基因组工具， 询问包括：快速扫描基因组，寻找导致相关表型的新突变; 使用微卫星和/或SNP标记，包括数据分析和新标记开发; 高通量微卫星等位基因分型和SNP基因分型; DNA测序;和高度纯化 来自JAX小鼠品系的DNA，通常用于实验中作为对照。基因组科学（GS） 包括以下服务：1）等位基因分型和测序; 2）单核苷酸多态性 基因分型; 3）精细作图;和4）DNA资源。GS为研究人员提供了访问状态- 用于基因组扫描、等位基因分型和测序的最先进的仪器、试剂和专业知识， 包括项目规划和数据分析方面的支助。测序和等位基因分型以前 获得CCSG支持。CCSG现在要求为SNP基因分型服务和罚款提供资金 测绘实验室，已分别运作2年和3年， 根据癌症中心成员的要求提供额外功能的记录。开始投产 1982年，DNA资源维护和分发高度纯化的基因组DNA，这是使用几乎 所有中心的研究人员在基因组分析实验，包括自发克隆对照 突变。基因组科学，在研究实验室第4单元占用847平方英尺的实验室空间 和遗传资源大楼，雇用了四名分子技术专家，四个实验室 技术人员都向高级经理分子遗传学家报告。项目负责人Jurgen Naggert，a 分子遗传学家，负责这项收费服务他与癌症中心 用户，服务人员和中心管理，以确保研究需求得到满足， 成本效益和技术上的最新方式。

The Genome Sciences group provides researchers with multiple complementary tools for genome interrogation including: rapid scanning of genomes for new mutations causing relevant phenotypes; mapbuilding using microsatellite and/or SNP markers, including data analysis and new marker development; high throughput microsatellite allele typing and SNP genotyping; DNA sequencing; and highly purified DNA from JAX mouse strains that is used routinely in experiments as controls. Genome Sciences (GS) comprises the following services: 1) Allele Typing & Sequencing; 2) Single Nucleotide Polymorphism genotyping; 3) Fine Mapping; and 4) the DNA Resource. GS provides researchers with access to stateof- the-art instrumentation, reagents and expertise for genome scanning, allele typing, and sequencing, including support in project planning and data analysis. Sequencing and Allele typing have previously received CCSG support. CCSG funds are now requested for the SNP Genotyping Service and the Fine Mapping Laboratory, which have been in operation for 2 and 3 years, respectively, with well established records of delivering additional functionality as required by Cancer Center members. Operating since 1982, the DNA Resource maintains and distributes highly purified genomic DNA, which is used by virtually all Center researchers for controls in genome analysis experiments including the cloning of spontaneous mutations. Genome Sciences, which occupies 847 ft2 of laboratory space in Research Laboratory Unit 4 and the Genetic Resources Building, employs four molecular technologists, and four laboratory technicians all reporting to a senior manager molecular geneticist. Project Leader Jurgen Naggert, a molecular geneticist, oversees this fee-for-service operation. He communicates with the Cancer Center users, Service staff and Center Administration to ensure that research needs are met in the most efficient, cost-effective and technically current manner.