Identification of New Mechanisms in Insulin Resistance

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Type II diabetes is a major cause of disease in Australia. Resistance of the liver to the effects of insulin plays a key role in the uncontrolled blood glucose levels in this disease. In this proposal, we will combine state-of-the-art protein chemistry techniques with advanced statistical analysis to identify the pathways driving liver insulin resistance. We will also predict clinically-approved drugs that may reverse these changes, to guide drug development for future therapeutic gain.