Identification of New Mechanisms in Insulin Resistance

胰岛素抵抗新机制的鉴定

• 批准号: nhmrc : 1120475
• 负责人: Dr Mark Larance
• 金额: $ 32.63万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/identification-new-mechanisms-insulin-resistance/946540
• 关键词: Identification; New; Mechanisms; Insulin; Resistance

Type II diabetes is a major cause of disease in Australia. Resistance of the liver to the effects of insulin plays a key role in the uncontrolled blood glucose levels in this disease. In this proposal, we will combine state-of-the-art protein chemistry techniques with advanced statistical analysis to identify the pathways driving liver insulin resistance. We will also predict clinically-approved drugs that may reverse these changes, to guide drug development for future therapeutic gain.

II型糖尿病是澳大利亚的主要疾病。肝脏对胰岛素作用的抵抗在这种疾病中不受控制的血糖水平中起着关键作用。在这个建议中，我们将结合联合收割机国家的最先进的蛋白质化学技术与先进的统计分析，以确定驱动肝脏胰岛素抵抗的途径。我们还将预测可能逆转这些变化的临床批准药物，以指导未来治疗收益的药物开发。