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A HLA Mouse Model for Gluten Sensitivity and Enteropathy

A HLA Mouse Model for Gluten Sensitivity and Enteropathy
麸质敏感性和肠病的 HLA 小鼠模型
批准号：
8089764
负责人：
Joseph A Murray
金额：
$39.43万
依托单位：
MAYO CLINIC ROCHESTER
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
项目状态：
已结题
起止时间：
2010-07-15 至 2012-06-30
来源：
https://reporter.nih.gov/project-details/8089764
关键词：
AchievementAddressAdenocarcinomaAffectAllelesAntigensAutoimmunityBarleyBullaCD4 Positive T LymphocytesCanned FoodsCeliac DiseaseCerealsChildChildhoodChronicComplexDataDermatitis HerpetiformisDevelopmentDiagnosisDietDiseaseElementsEnvironmentEpithelial CellsEvaluationEventExcess MortalityExcisionExposure toFailureFoodFundingGene CombinationsGenesGeneticGenetic Predisposition to DiseaseGenetic RiskGenotypeGliadinGlutenGrantHaplotypesHomeostasisHumanImmuneImmune System DiseasesImmune responseImmune systemImmunizationImmunologic FactorsImmunosuppressive AgentsIncidenceIndividualInflammatoryIngestionInjection of therapeutic agentInterleukin-10IntestinesKnock-outKnowledgeLeadLeftLifeLinkage DisequilibriumLymphomaMaintenanceMalignant NeoplasmsMeasuresMemoryMethodsMinorityMissionModelingMorbidity - disease rateMucous MembraneMusNon-MalignantOralPathogenesisPatientsPeptidesPopulationProcessProductionProteinsRegulatory ElementResearch DesignRiskRoleRye cerealSystemT cell responseT-Cell ProliferationT-LymphocyteTNFRSF10A geneTimeTransgenic MiceTransgenic OrganismsUnited States National Institutes of HealthVirus DiseasesWeaningWheatbaseburden of illnesschemokinecytokinedisabilityfeedinggastrointestinalgastrointestinal infectionhuman diseaseinterestlong term memorymonocytemortalitymouse modelnovelnovel therapeutic interventionpreventpublic health relevance

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