A HLA Mouse Model for Gluten Sensitivity and Enteropathy

麸质敏感性和肠病的 HLA 小鼠模型

• 批准号: 8089764
• 负责人: Joseph A Murray
• 金额: $ 39.43万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-15 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8089764
• 关键词: Achievement; Address; Adenocarcinoma; Affect; Alleles; Antigens; Autoimmunity; Barley; Bulla; CD4 Positive T Lymphocytes; Canned Foods; Celiac Disease; Cereals; Child; Childhood; Chronic; Complex; Data; Dermatitis Herpetiformis; Development; Diagnosis; Diet; Disease; Elements; Environment; Epithelial Cells; Evaluation; Event; Excess Mortality; Excision; Exposure to; Failure; Food; Funding; Gene Combinations; Genes; Genetic; Genetic Predisposition to Disease; Genetic Risk; Genotype; Gliadin; Gluten; Grant; Haplotypes; Homeostasis; Human; Immune; Immune System Diseases; Immune response; Immune system; Immunization; Immunologic Factors; Immunosuppressive Agents; Incidence; Individual; Inflammatory; Ingestion; Injection of therapeutic agent; Interleukin-10; Intestines; Knock-out; Knowledge; Lead; Left; Life; Linkage Disequilibrium; Lymphoma; Maintenance; Malignant Neoplasms; Measures; Memory; Methods; Minority; Mission; Modeling; Morbidity - disease rate; Mucous Membrane; Mus; Non-Malignant; Oral; Pathogenesis; Patients; Peptides; Population; Process; Production; Proteins; Regulatory Element; Research Design; Risk; Role; Rye cereal; System; T cell response; T-Cell Proliferation; T-Lymphocyte; TNFRSF10A gene; Time; Transgenic Mice; Transgenic Organisms; United States National Institutes of Health; Virus Diseases; Weaning; Wheat; base; burden of illness; chemokine; cytokine; disability; feeding; gastrointestinal; gastrointestinal infection; human disease; interest; long term memory; monocyte; mortality; mouse model; novel; novel therapeutic intervention; prevent; public health relevance