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Leptin Transport across the BBB: The Role of ObR (+) astrocytes

Leptin Transport across the BBB: The Role of ObR (+) astrocytes
瘦素跨 BBB 运输：ObR ( ) 星形胶质细胞的作用
批准号：
8074152
负责人：
ABBA J KASTIN
金额：
$22.2万
依托单位：
LSU PENNINGTON BIOMEDICAL RESEARCH CTR
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
项目状态：
已结题
起止时间：
2010-07-05 至 2011-06-30
来源：
https://reporter.nih.gov/project-details/8074152
关键词：
AddressAdipocytesAdipose tissueAdultAffectAlbuminsAnimalsApicalAstrocytesBiological AssayBloodBlood - brain barrier anatomyBrainCardiovascular systemCell CommunicationCellsCerebrumChemicalsCoculture TechniquesD GlutamateDataDegradation PathwayDextransDietDiffusionEffector CellEndocytosisEndosomesEndothelial CellsExocytosisFatty acid glycerol estersGenerationsGolgi ApparatusGrantHalf-LifeHigh Pressure Liquid ChromatographyHomeostasisHormonesHyperlipidemiaHypothalamic structureIn VitroInjection of therapeutic agentKineticsKnockout MiceLabelLaboratoriesLeptinLinkLocationLysosomesMembraneMessenger RNAMetabolicMetabolic syndromeModelingMorbid ObesityMusMutationNeuronsNeurosecretory SystemsNutrientObesityPaperPathway interactionsPermeabilityPhenotypePlayPrevalenceProcessProteinsRecyclingRegulationReportingRoleSeriesSerineSideSignal TransductionSleep Apnea SyndromesSpecificitySystemTestingTight JunctionsTimeTissuesUp-RegulationWorkabstractingadipokinesastrogliosiscancer complicationcombatdextranfluorocitrateimmunocytochemistryin vitro Modelin vivoinhibitor/antagonistleptin receptormonolayermouse modelmulticatalytic endopeptidase complexmutantnew therapeutic targetnoveloverexpressionpublic health relevancereceptorresponseuptake

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