Conduct Hit-to-Lead Progression Studies on Interventional Agents: Identification of Anti-HIV Lead Compounds

HIV治疗药物的临床前服务：这些不确定交付/不确定数量合同的目的是为外部科学界提供研究材料和临床前产品开发支持，以支持研究者发起的研究或与私营部门或学术伙伴合作产生的候选产品。工作范围包括从基础研究和初始产品发现到临床试验和/或产品许可所需的活动。这些服务还可用于支持产品发现和开发，从而向食品和药物管理局（FDA）提交研究性新药申请（IND），研究性器械豁免（IDE）和/或新药申请（NDA）。NIAID艾滋病司将主要利用这些合同更快速有效地填补关键的开发和资源缺口，并将有希望的产品推向临床试验。这项任务的目的是开发具有阻断HIV感染、抑制HIV基因表达和复制或治愈HIV感染感染细胞活性的潜在化合物。

Preclinical Services for HIV Therapeutics: The purpose of these Indefinite Delivery/Indefinite Quantity contracts is to provide the extramural scientific community with research materials and preclinical product development support for candidate products that emerge from investigator-initiated research studies or from collaborations with private sector or academic partners. The scope of work encompasses activities that range from basic research and initial product discovery to activities required for clinical trials and/or product licensure. These services may also be used to support product discovery and development leading to Investigational New Drug Application (IND), Investigational Device Exemption (IDE), and/or New Drug Application (NDA) filings with the Food and Drug Administration (FDA). NIAID Division of AIDS will primarily use these contracts to fill critical development and resource gaps more rapidly and efficiently and advance promising products into clinical testing. The purpose of this task order is to develop potential compounds with activity to block HIV infection, inhibit HIV gene expression and replication, or cure infected cells of HIV infection.