Training Programs in Cancer Pharmacology

描述(由申请人提供)：本申请建议开发一个多学科癌症药理学培训计划(CPTP)，为博士后和博士后学员提供凯斯西储大学目前不存在的培训机会。在不久的将来，癌症治疗和预防方面的重大进展将来自多学科方法，以阐明肿瘤发生和发展的基础过程，并开发和实施癌症治疗和预防的新策略。该计划的目标是教授癌症药理学的基础知识，并培训学生使用涉及多学科互动的癌症药理学方法。因此，该计划将有助于填补目前个人的不足，这些人可以在不同学科之间自由移动，并与来自不同领域的科学家进行富有成效的互动，以开发下一代化疗药物。这些目标将通过提供的课程和教师提供的多学科研究经验来实现。项目主任Noa Noy和咨询委员会将为在癌症药理学领域的多学科环境中招募和培训博士后和博士后科学家提供所需的持续领导。具有不同互补专业知识的35名教师导师将被分成四个子项目：癌症生物学、癌症药物设计和交付、成像和癌症系统生物学。每个受训者都将有来自其中两个项目的研究导师。作为癌症研究人员，这一计划的导师有着非常出色的成就。他们是美国国立卫生研究院76项拨款的首席研究员或项目负责人。除了培训补助金，29名导师还获得了NIH资助(主要是通过NCI)的研究补助金。在过去的10年里，导师们培养了210名博士后学员和192名博士后研究员；他们的实验室目前有126名博士后学员和111名博士后学员。 公共卫生相关性：该应用程序建议开发一个多学科癌症药理学培训计划(CPTP)，为博士后和博士后学员提供凯斯西储大学目前不存在的培训机会。该计划的目标是教授癌症药理学的基础知识，并培训学生使用涉及多学科互动的癌症药理学方法。因此，该计划将有助于填补目前个人的不足，这些人可以在不同学科之间自由移动，并与来自不同领域的科学家进行富有成效的互动，以开发下一代化疗药物。这些目标将通过课程作业和多学科研究经验来实现。项目主任Noa Noy和咨询委员会将为在癌症药理学领域的多学科环境中招募和培训博士后和博士后科学家提供所需的持续领导。36名具有不同互补专业知识的教师导师将被分成四个子项目：癌症生物学、癌症药物设计和交付、成像和癌症系统生物学。每个受训者都将有来自其中两个项目的研究导师。

DESCRIPTION (provided by applicant): This application proposes to develop a multidisciplinary Cancer Pharmacology Training Program (CPTP) to provide predoctoral and postdoctoral trainees with a training opportunity that does not currently exist at Case Western Reserve University. Major advances in the treatment and prevention of cancer in the near future will emerge from multidisciplinary approaches to elucidating the processes that underlie tumor initiation and progression and to developing and implementing novel strategies for therapy and prevention of cancer. The goals of the program are to teach the fundamentals of cancer pharmacology, and to train students in approaches to cancer pharmacology that involve multidisciplinary interactions. The program will thus help fill the current deficit of individuals who can move freely between disciplines and productively interact with scientists from various areas to develop the next generation of chemotherapeutic agents. These goals will be accomplished through the courses that are offered and the multidisciplinary research experiences that will be available from the faculty. The program director, Noa Noy, and the advisory committee will provide the sustained leadership required for the recruitment and training of both predoctoral and postdoctoral scientists in the multidisciplinary environment of the field of cancer pharmacology. The 35 faculty mentors with diverse complementary expertise will be grouped into four sub-programs: Cancer biology, Cancer Drug Design and Delivery, Imaging, and Cancer Systems biology. Each trainees will have research mentors from two of these programs. The mentors on this proposed program have a very strong record of accomplishment as cancer researchers. They are Principal Investigators or Project Leaders on 76 NIH grants. Apart from training grants, 29 of the mentors have NIH-funded (primarily through NCI) research grants. Over the past 10-years, the mentors have trained 210 predoctoral students and 192 postdoctoral fellows; they currently have 126 predoctoral and 111 postdoctoral trainees in their laboratories. PUBLIC HEALTH RELEVANCE: This application proposes to develop a multidisciplinary Cancer Pharmacology Training Program (CPTP) to provide predoctoral and postdoctoral trainees with a training opportunity that does not currently exist at Case Western Reserve University. The goals of the program are to teach the fundamentals of cancer pharmacology, and to train students in approaches to cancer pharmacology that involve multidisciplinary interactions. The program will thus help fill the current deficit of individuals who can move freely between disciplines and productively interact with scientists from various areas to develop the next generation of chemotherapeutic agents. These goals will be accomplished through coursework and through multidisciplinary research experiences. The program director, Noa Noy, and the advisory committee will provide the sustained leadership required for the recruitment and training of both predoctoral and postdoctoral scientists in the multidisciplinary environment of the field of cancer pharmacology. 36 faculty mentors with diverse complementary expertise will be grouped into four sub-programs: Cancer biology, Cancer Drug Design and Delivery, Imaging, and Cancer Systems biology. Each trainees will have research mentors from two of these programs.