2010 FASEB Conference on the Retinoids

申请者描述(由申请者提供)：本申请请求部分资助将于2010年6月13-18日在亚利桑那州Careless的Careless度假村举行的第15届美国实验生物学学会联合会(FASE B)关于维甲酸的夏季研究会议。这个一年两次的研究会议出席人数非常多(在过去25年中，出席人数从125到200人不等)，并且仍然是唯一一次涉及维甲酸生物学全光谱的主要国内和国际会议。在过去的二十年里，我们对维甲酸的作用机制和生物学功能的了解迅速增加。然而，在正常的人类生理学和病理生理学中，仍有许多关于视黄醇作用的知识需要了解。为了满足这种对信息的需求，目前正在进行大量以维甲酸为重点的研究活动(NIH CRISP数据库表明，目前有284笔NIH资助的资金涉及维甲酸生物学)。2010年会议将包括一次全体演讲、平台演讲和海报会议，使科学与会者能够交流新的研究成果。会议的主要议题包括：(1)维甲酸代谢和稳态；(2)维甲酸受体；(3)维甲酸作用的酶控制；(4)维甲酸在视觉中的作用；(5)维甲酸与癌症；(6)维甲酸的生理作用；(7)维甲酸在发育中的作用；(8)维甲酸对细胞生长和分化的调节；(9)维甲酸对干细胞生物学的调节。拟议中的维甲酸会议的总体目标是聚集一群研究人员(包括高级科学家、职业中期科学家、初级科学家、博士后研究员和研究生)，他们在不同的学科工作(作为生物化学家、分子生物学家、营养学家、癌症研究人员、发育生物学家、视觉研究人员、细胞生物学家、生物物理学家、结构生物学家、免疫学家、化学家和临床医生)，展示和讨论他们对类维A酸的共同关注的最新研究成果。这次会议将提供一个论坛，对最近的研究进行批判性审查，并发展新的研究想法和合作。这将刺激新的研究，最终将为维甲酸在预防疾病和维持健康方面的基本行动提供必要的洞察。 叙述性 维甲酸是维生素A的活性形式，对人类健康的许多方面都有广泛的影响，包括视力、胚胎发育、免疫和不同类型细胞的分化。维甲酸是治疗皮肤病和癌症的重要药物，它们与糖尿病/肥胖症和某些眼病有关。这个一年两次的研究会议提供了唯一一个主要的国内和国际论坛，讨论维甲酸生物学的全部范围。其目标是促进科学交流和新的研究，为维甲酸在疾病预防和治疗中的作用提供必要的见解。

DESCRIPTION (provided by applicant): This application requests partial support for the 15th Federation of American Societies for Experimental Biology (FASEB) Summer Research Conference on Retinoids to be held at the Carefree Resort in Carefree, Arizona in June 13-18, 2010. This bi-annual research conference has been very well attended (ranging from 125 to 200 attendees over the past 25 years) and remains the sole major national and international conference that addresses the full spectrum of retinoid biology. Our understanding of the mechanisms of action and the biological functions of retinoids has increased rapidly over the last two decades. Nevertheless, there is much that still needs to be learned regarding retinoid actions in both normal human physiology and pathophysiology. To meet this need for information, there is a great deal of ongoing research activity focused on the retinoids (the NIH CRISP database indicates that there are currently 284 funded NIH grants involving retinoid biology). The 2010 conference will consist of a plenary lecture, platform presentations and poster sessions that will allow for the exchange of new research findings amongst scientific attendees. The main topics to be addressed at the conference include: (1) retinoid metabolism and homeostasis; (2) retinoid receptors; (3) enzymatic control of retinoic acid action; (4) retinoids in vision; (5) retinoids in cancer; (6) physiological actions of retinoids; (7) retinoids in development; (8) retinoid regulation of cell growth and differentiation; and (9) retinoid regulation of stem cell biology. The overall goal of the proposed conference on retinoids is to bring together a group of investigators (including senior scientists, mid-career scientists, junior scientists, postdoctoral fellows, and graduate students) who work in diverse disciplines (as biochemists, molecular biologists, nutritional scientists, cancer researchers, developmental biologists, vision researchers, cell biologists, biophysicists, structural biologists, immunologists, chemists, and clinicians) to present and discuss their newest research findings that share a common focus on the retinoids. This conference will provide a forum for the critical review of recent research and for the development of new research ideas and collaborations. This will stimulate new investigations that in time will provide needed insight into the essential actions of retinoids in preventing disease and maintaining health. Narrative Retinoids, the active forms of vitamin A, have wide ranging effects on many aspects of human health including vision, embryonic development, immunity, and differentiation of diverse cell types. Retinoids are important therapeutics for skin disorders and cancer, and they are involved in diabetes/obesity and certain ocular diseases. This bi-annual research conference provides the sole major national and international forum that addresses the full spectrum of retinoid biology. Its goal is to stimulate scientific exchange and new investigations that will provide needed insights into the roles of retinoids in disease prevention and treatment.