2010 FASEB Conference on the Retinoids

说明（由申请人提供）：本申请请求对将于 2010 年 6 月 13 日至 18 日在亚利桑那州 Carefree 的 Carefree Resort 举行的第 15 届美国实验生物学会联合会 (FASEB) 夏季类视黄醇研究会议提供部分支持。这次一年两次的研究会议出席人数众多（过去 25 年来，与会者人数从 125 人到 200 人不等），并且仍然是唯一的主要国内和国际会议会议讨论了类视黄醇生物学的全部范围。在过去的二十年里，我们对类维生素A的作用机制和生物学功能的了解迅速加深。然而，关于类视黄醇在正常人体生理学和病理生理学中的作用，仍然有很多东西需要了解。为了满足这种信息需求，目前有大量针对类视黄醇的研究活动正在开展（NIH CRISP 数据库表明，目前有 284 项 NIH 资助项目涉及类视黄醇生物学）。 2010 年的会议将包括全体演讲、平台演示和海报会议，以便科学与会者交流新的研究成果。会议讨论的主要议题包括：（1）类维生素A代谢与稳态； (2)类视黄醇受体； (3)视黄酸作用的酶促控制； (4) 视觉中的类维生素A； (5)类维生素A在癌症中的作用； (6)类维生素A的生理作用； (7) 正在开发的类维生素A； (8)类视黄醇对细胞生长和分化的调节； (9)类维生素A对干细胞生物学的调节。拟议的类视黄醇会议的总体目标是聚集一群不同学科（生物化学家、分子生物学家、营养科学家、癌症研究人员、发育生物学家、视觉研究人员、细胞生物学家、生物物理学家、结构生物学家、免疫学家、化学家和临床医生）的研究人员（包括资深科学家、职业中期科学家、初级科学家、博士后研究员和研究生），展示和讨论他们共同关注的最新研究成果类维生素A。这次会议将为对近期研究进行批判性审查以及新研究理念和合作的发展提供一个论坛。这将刺激新的研究，及时为类维生素A在预防疾病和维持健康方面的基本作用提供必要的见解。 叙事 类维生素A是维生素A的活性形式，对人类健康的许多方面具有广泛的影响，包括视力、胚胎发育、免疫和不同细胞类型的分化。类维生素A是治疗皮肤病和癌症的重要药物，它们与糖尿病/肥胖症和某些眼部疾病有关。这个一年两次的研究会议提供了唯一一个主要的国内和国际论坛，讨论类视黄醇生物学的各个方面。其目标是促进科学交流和新的研究，为类维生素A在疾病预防和治疗中的作用提供必要的见解。

DESCRIPTION (provided by applicant): This application requests partial support for the 15th Federation of American Societies for Experimental Biology (FASEB) Summer Research Conference on Retinoids to be held at the Carefree Resort in Carefree, Arizona in June 13-18, 2010. This bi-annual research conference has been very well attended (ranging from 125 to 200 attendees over the past 25 years) and remains the sole major national and international conference that addresses the full spectrum of retinoid biology. Our understanding of the mechanisms of action and the biological functions of retinoids has increased rapidly over the last two decades. Nevertheless, there is much that still needs to be learned regarding retinoid actions in both normal human physiology and pathophysiology. To meet this need for information, there is a great deal of ongoing research activity focused on the retinoids (the NIH CRISP database indicates that there are currently 284 funded NIH grants involving retinoid biology). The 2010 conference will consist of a plenary lecture, platform presentations and poster sessions that will allow for the exchange of new research findings amongst scientific attendees. The main topics to be addressed at the conference include: (1) retinoid metabolism and homeostasis; (2) retinoid receptors; (3) enzymatic control of retinoic acid action; (4) retinoids in vision; (5) retinoids in cancer; (6) physiological actions of retinoids; (7) retinoids in development; (8) retinoid regulation of cell growth and differentiation; and (9) retinoid regulation of stem cell biology. The overall goal of the proposed conference on retinoids is to bring together a group of investigators (including senior scientists, mid-career scientists, junior scientists, postdoctoral fellows, and graduate students) who work in diverse disciplines (as biochemists, molecular biologists, nutritional scientists, cancer researchers, developmental biologists, vision researchers, cell biologists, biophysicists, structural biologists, immunologists, chemists, and clinicians) to present and discuss their newest research findings that share a common focus on the retinoids. This conference will provide a forum for the critical review of recent research and for the development of new research ideas and collaborations. This will stimulate new investigations that in time will provide needed insight into the essential actions of retinoids in preventing disease and maintaining health. Narrative Retinoids, the active forms of vitamin A, have wide ranging effects on many aspects of human health including vision, embryonic development, immunity, and differentiation of diverse cell types. Retinoids are important therapeutics for skin disorders and cancer, and they are involved in diabetes/obesity and certain ocular diseases. This bi-annual research conference provides the sole major national and international forum that addresses the full spectrum of retinoid biology. Its goal is to stimulate scientific exchange and new investigations that will provide needed insights into the roles of retinoids in disease prevention and treatment.