Identification of novel genes predisposing to male breast cancer, their prevalence and associated cancer risks.

男性乳腺癌(MBC)是一种罕见且研究不足的疾病。利用最新的技术，这项研究将识别导致家族性MBC的新基因，以帮助对受影响的男子及其家人进行遗传咨询和风险评估。这些新基因和所有已知的乳腺癌基因的频率将在第二组受影响的男性和女性乳腺癌风险增加的家庭中进行评估。通过更好地了解MBC的成因，我们可以改进其管理。

Male breast cancer (MBC) is rare and understudied. Using the latest technology, this study will identify new genes which cause familial MBC to aid in the genetic counselling and risk assessment of an affected man and his family. The frequency of these novel genes, and all known breast cancer genes will be assessed in a second group of affected men as well as families with an increased female breast cancer risk. By better understanding the cause of MBC, we can improve its management.