Identification of novel genes predisposing to familial colorectal cancer by full exome sequencing

通过全外显子组测序鉴定易患家族性结直肠癌的新基因

• 批准号: nhmrc : 1028374
• 负责人: A/Pr Alison Trainer
• 金额: $ 10.55万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/identification-novel-genes-exome-sequencing/110631
• 关键词: Identification; novel; genes; predisposing; familial

A third of people who develop bowel cancer have a family history of the condition. Currently, we only understand the genes involved in a small number of these families. This proposal will use new genetic techniques to look for gene faults in the remaining families by sequencing all an individual’s genes simultaneously. By identifying new genes, we can accurately assess family members’ bowel cancer risk, effectively target surveillance and help reduce their risk of developing bowel cancer.

三分之一的肠癌患者有家族病史。目前，我们只了解这些家族中少数家族的基因。这项提议将使用新的遗传技术，通过同时对所有个体的基因进行测序，来寻找剩余家族中的基因缺陷。通过识别新基因，我们可以准确评估家庭成员的肠癌风险，有效地进行靶向监测，并帮助降低他们患肠癌的风险。