Synchronization of Drosophila Circadian Rhythms by temperature cycles
温度循环同步果蝇昼夜节律
基本信息
- 批准号:7760191
- 负责人:
- 金额:$ 32.18万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2008
- 资助国家:美国
- 起止时间:2008-04-01 至 2012-01-31
- 项目状态:已结题
- 来源:
- 关键词:AccidentsAddressAffectAnimal ModelAnimalsAttentionBehaviorBehavioralBehavioral GeneticsCircadian RhythmsComplexCuesCyanobacteriumDataDiseaseDrosophila genusDrosophila melanogasterElementsEnvironmentEukaryotaFutureGenesGeneticHealthHumanJet Lag SyndromeLifeLightMammalsMedicalMental disordersMolecularMolecular GeneticsMood DisordersMutationNeuronsNeurosciencesOrganismPacemakersPathway interactionsPhasePhysiologicalPhysiologyPlayPropertyRegulationRoleSeasonal Affective DisorderSolutionsStimulusStructureTemperatureTestingThermoreceptorsTimeVariantWorkbasecircadian behavioral rhythmscircadian pacemakerday lengthflylight intensitynovelpublic health relevanceresponseshift worktherapy design
项目摘要
DESCRIPTION (provided by applicant): Our environment constantly affects our behavior. The circadian pacemaker is one of the best-characterized interfaces that connect complex behaviors with the environment. It helps most organisms to anticipate and adapt to the changes occurring every day in their surrounding. We are beginning to have a good sense of how these self-sustained rhythms function, but their synchronization is still poorly understood. This is a critical question, since improperly synchronized circadian rhythms would be of no use or even detrimental to the survival of an organism or to human health. Light input pathways have been recently studied in detail, but much less attention has been given to temperature input pathways, even though these inputs play a central role for circadian rhythm synchronization in many organisms. We propose to study temperature synchronization of the Drosophila pacemaker to answer three fundamental questions using a combination of genetic, molecular and behavioral approaches. In aim 1 we will determine how temperature synchronizes circadian behavior and identify the neuronal structures necessary for this synchronization. With aim 2 we will study genetically the mechanisms underlying the temperature input pathway. In aim 3 we will determine how the circadian pacemaker responds to temperature cycle at a molecular level. Our work should reveal novel mechanisms underlying a fundamental property of circadian rhythms: their synchronization with the environment. This should ultimately result in a better understanding of the ailments associated with improper circadian rhythm synchronizations, such as jet lag, seasonal affective disorder, and desynchronization due to shift work.
PUBLIC HEALTH RELEVANCE: Circadian clocks time the physiology and behavior of most animals on a daily basis. We will study how temperature cycles synchronize the circadian clock of the model organism Drosophila to understand the general principles governing the synchronization of circadian rhythms with the day/night cycles. Since the mechanisms generating circadian rhythms are remarkably conserved in the animal kingdom, our work should ultimately contribute to the design of therapies aimed at alleviating ailments associated with abnormal synchronization of the human circadian clock, such as jet lag and mood disorders.
描述(由申请人提供):我们的环境不断影响我们的行为。昼夜节律起搏器是将复杂行为与环境联系起来的最具特色的接口之一。它帮助大多数生物体预测并适应周围环境每天发生的变化。我们开始对这些自我维持的节律如何发挥作用有了很好的认识,但对它们的同步性仍然知之甚少。这是一个关键问题,因为昼夜节律同步不当对生物体的生存或人类健康没有任何用处,甚至有害。最近对光输入途径进行了详细研究,但对温度输入途径的关注却少得多,尽管这些输入在许多生物体中的昼夜节律同步中发挥着核心作用。我们建议研究果蝇起搏器的温度同步,以结合遗传、分子和行为方法来回答三个基本问题。在目标 1 中,我们将确定温度如何同步昼夜节律行为,并确定这种同步所需的神经元结构。对于目标 2,我们将从遗传学角度研究温度输入途径的机制。在目标 3 中,我们将确定昼夜节律起搏器如何在分子水平上响应温度周期。我们的工作应该揭示昼夜节律基本特性背后的新机制:它们与环境的同步。这最终应该有助于更好地理解与昼夜节律同步不当相关的疾病,例如时差、季节性情感障碍和轮班工作导致的不同步。
公共卫生相关性:昼夜节律时钟每天记录大多数动物的生理和行为。我们将研究温度循环如何使模式生物果蝇的生物钟同步,以了解控制昼夜节律与昼夜周期同步的一般原理。由于产生昼夜节律的机制在动物界中非常保守,我们的工作最终应该有助于设计旨在减轻与人类生物钟异常同步相关的疾病的疗法,例如时差和情绪障碍。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
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Patrick Emery其他文献
Patrick Emery的其他文献
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{{ truncateString('Patrick Emery', 18)}}的其他基金
Molecular and cellular mechanisms underlying circadian rhythms and sleep in Drosophila
果蝇昼夜节律和睡眠的分子和细胞机制
- 批准号:
10405908 - 财政年份:2022
- 资助金额:
$ 32.18万 - 项目类别:
Molecular and cellular mechanisms underlying circadian rhythms and sleep in Drosophila
果蝇昼夜节律和睡眠的分子和细胞机制
- 批准号:
10796266 - 财政年份:2022
- 资助金额:
$ 32.18万 - 项目类别:
Molecular and neural mechanisms generating and synchronizing circadian rhythms
产生和同步昼夜节律的分子和神经机制
- 批准号:
9923697 - 财政年份:2016
- 资助金额:
$ 32.18万 - 项目类别:
Molecular and neural mechanisms generating and synchronizing circadian rhythms
产生和同步昼夜节律的分子和神经机制
- 批准号:
9269237 - 财政年份:2016
- 资助金额:
$ 32.18万 - 项目类别:
The role of RNA binding proteins in the control of Drosophila circadian rhythms
RNA结合蛋白在果蝇昼夜节律控制中的作用
- 批准号:
8368915 - 财政年份:2012
- 资助金额:
$ 32.18万 - 项目类别:
The role of RNA binding proteins in the control of Drosophila circadian rhythms
RNA结合蛋白在果蝇昼夜节律控制中的作用
- 批准号:
8690108 - 财政年份:2012
- 资助金额:
$ 32.18万 - 项目类别:
The role of RNA binding proteins in the control of Drosophila circadian rhythms
RNA结合蛋白在果蝇昼夜节律控制中的作用
- 批准号:
8892202 - 财政年份:2012
- 资助金额:
$ 32.18万 - 项目类别:
The role of RNA binding proteins in the control of Drosophila circadian rhythms
RNA结合蛋白在果蝇昼夜节律控制中的作用
- 批准号:
8523917 - 财政年份:2012
- 资助金额:
$ 32.18万 - 项目类别:
Synchronization of Drosophila Circadian Rhythms by temperature cycles
温度循环同步果蝇昼夜节律
- 批准号:
7582325 - 财政年份:2008
- 资助金额:
$ 32.18万 - 项目类别:
Synchronization of Drosophila Circadian Rhythms by temperature cycles
温度循环同步果蝇昼夜节律
- 批准号:
8018680 - 财政年份:2008
- 资助金额:
$ 32.18万 - 项目类别:
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