Identification of novel mediators of bone catch-up growth

肌肉骨骼生长障碍会给儿童带来巨大的痛苦，并在新一代劳动力开始工作之前损害他们的健康。尽管存在这种相关性，但诱导受损骨骼生长恢复的非侵入性方法仍是一个未满足的需求，因为我们对这一过程的工作原理缺乏足够的了解。为了解决这一知识差距，我们建立了小鼠模型，这将使我们能够揭示胎儿代偿生长的介质，这些介质可以在出生后重新激活以促进骨骼生长。

Musculoskeletal growth disorders cause significant suffering in children and impair new workforce generations before their working life starts. Despite this relevance, non-invasive methods to induce growth recovery of impaired bones are an unmet need, as we lack sufficient understanding of how this process works. To address this knowledge gap, we generated mouse models that will allow us to reveal foetal mediators of compensatory growth that could be reactivated postnatally to boost bone growth.