Identification of proteins that structurally couple epidermal cells to somatosensory neurons
Identification of proteins that structurally couple epidermal cells to somatosensory neurons
批准号:
10390199
负责人:
JAY Z PARRISH
金额:
$44.15万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2021
资助国家:
美国
项目状态:
已结题
起止时间:
2021-09-21 至 2024-02-29
关键词:
AffectAgeAmericanAnatomyBiological AssayBiologyBiotinBiotinylationC FiberCell ShapeCell membraneCellsComplexCouplesCutaneousDevelopmentDiscriminationDrosophila ProteinsDrosophila genusDrug TargetingEpidermisErythrocytesEtiologyExhibitsFishesFree Nerve EndingFrequenciesGeneticGoalsHeterogeneityImageIndividualInflammation MediatorsIntractable PainInvertebratesKnowledgeLabelLigaseLinkLiquid ChromatographyMass Spectrum AnalysisMechanical StressMechanoreceptorsMediatingMediator of activation proteinMerkel CellsModelingMolecularMorphogenesisMovementNervous system structureNeuritesNeuronsNociceptionNociceptive StimulusNociceptorsOpioid ReceptorOpticsPacinian CorpusclesPainPain managementPathologicPerceptionPhysiologicalPlayPopulationPrevalenceProteinsProteomicsPruritusPublic HealthQuality of lifeRadialResearchRoleSchwann CellsSensoryShapesSignal TransductionSkinStimulusStructureSynapsesSystemTherapeuticTouch sensationZebrafishbasechronic painclinically relevantcomparativeexperienceflygenomic locusin vivoinsightinterestkeratinocyteknock-downloss of functionneurogeneticsneuron developmentnovelnovel therapeuticspain perceptionpressureprotein functionreceptorreconstitutionresponsesensorsensory stimulusside effectsomatosensorytool
中文摘要
摘要
英文摘要
ABSTRACT
Epidermal cells provide the first point of contact for sensory stimuli and are innervated by somatosensory neurons
(SSNs) that shape our experience of the world. Both SSNs and epidermal cells are of great clinical relevance;
SSNs are mediators of physiological and pathological pain, and some pathological skin conditions are associated
with debilitating pain and itch. However, our understanding of roles that epidermal cells play in SSN development
and function, particularly nociception, remain limited aside from a few well-studied examples. Characterizing
these important intercellular interactions is complicated by the heterogeneity and complexity of vertebrate
nervous systems. Here, we propose to use an integrated cross-species approach to identify molecular mediators
of an evolutionarily conserved intracellular interaction that involves the wrapping of SSN neurites by epidermal
cells. The conservation of this intercellular interaction and the preferential ensheathment of nociceptors
compared to other SSNs suggest that these sheaths may play key roles in development and function of
nociceptive SSNs. First, we will exploit the advantages of Drosophila neurogenetics to label epidermal sheath-
associated proteins for identification by mass-spectroscopy and downstream functional analysis in vivo. Second,
we will extend our comparative analysis of invertebrate and vertebrate epidermal sheaths, combining loss-of-
function studies in zebrafish and cross-species rescue studies to define conserved functions of a central
regulator of sheath maturation. Successful completion of this project will provide insight into the molecular
machinery that anatomically couples epidermal cells to nociceptors and contributes to nociceptor development
and function. Given the enormous impact of pathological pain on quality of life – chronic pain affects more than
one in three Americans – understanding how epidermal cells modulate nociceptive SSN function is of great
interest for development of novel therapeutics for pain management.
期刊论文(2)
专著(0)
科研奖励(0)
会议论文
CryoET shows cofilactin filaments inside the microtubule lumen.
CryoET 显示微管腔内的 cofilactin 丝。
DOI:
10.1101/2023.03.31.535077
发表时间:
2023
期刊:
bioRxiv : the preprint server for biology
影响因子:
--
作者:
[Santos,CamillaVentura, Rogers,StephenL, Carter,AndrewP]
通讯作者:
Carter,AndrewP
Extrinsic signals required for maintenance of dendrite coverage
-
批准号:8535230
-
项目类别:
-
资助金额:$32.61万
-
财政年份:2011
-
负责人:JAY Z PARRISH
-
依托单位:
Extrinsic signals required for maintenance of dendrite coverage
-
批准号:8219746
-
项目类别:
-
资助金额:$33.71万
-
财政年份:2011
-
负责人:JAY Z PARRISH
-
依托单位:
Extrinsic signals required for maintenance of dendrite coverage
-
批准号:8322031
-
项目类别:
-
资助金额:$33.8万
-
财政年份:2011
-
负责人:JAY Z PARRISH
-
依托单位:
Extrinsic signals required for maintenance of dendrite coverage
-
批准号:9297382
-
项目类别:
-
资助金额:$33.8万
-
财政年份:2011
-
负责人:JAY Z PARRISH
-
依托单位:
Extrinsic signals required for maintenance of dendrite coverage
-
批准号:8910794
-
项目类别:
-
资助金额:$33.8万
-
财政年份:2011
-
负责人:JAY Z PARRISH
-
依托单位:
Extrinsic signals required for maintenance of dendrite coverage
-
批准号:8715870
-
项目类别:
-
资助金额:$33.46万
-
财政年份:2011
-
负责人:JAY Z PARRISH
-
依托单位:
Genetic Analysis of Dendrite Maintenance in Drosophila Sensory Neurons
-
批准号:8076747
-
项目类别:
-
资助金额:$24.48万
-
财政年份:2010
-
负责人:JAY Z PARRISH
-
依托单位:
Genetic Analysis of Dendrite Maintenance in Drosophila Sensory Neurons
-
批准号:8257545
-
项目类别:
-
资助金额:$24.08万
-
财政年份:2010
-
负责人:JAY Z PARRISH
-
依托单位:
Genetic Analysis of Dendrite Maintenance in Drosophila Sensory Neurons
-
批准号:7998972
-
项目类别:
-
资助金额:$24.89万
-
财政年份:2010
-
负责人:JAY Z PARRISH
-
依托单位:
Genetic Analysis of Dendrite Maintenance in Drosophila Sensory Neurons
-
批准号:7619266
-
项目类别:
-
资助金额:$8.54万
-
财政年份:2008
-
负责人:JAY Z PARRISH
-
依托单位:
Genetic Analysis of Dendrite Maintenance in Drosophila Sensory Neurons
-
批准号:7448764
-
项目类别:
-
资助金额:$8.54万
-
财政年份:2008
-
负责人:JAY Z PARRISH
-
依托单位:
Transcriptional regulators of dendrite development
-
批准号:6892306
-
项目类别:
-
资助金额:$4.83万
-
财政年份:2004
-
负责人:JAY Z PARRISH
-
依托单位:
Transcriptional regulators of dendrite development
-
批准号:6793425
-
项目类别:
-
资助金额:$4.3万
-
财政年份:2004
-
负责人:JAY Z PARRISH
-
依托单位:
国内基金
海外基金
登录
查看更多内容
补阳还五汤通过AGE-RAGE通路调控脓毒症免疫失衡的机制与转化研究
-
批准号:JCZRLH202601523
-
项目类别:省市级项目
-
资助金额:--
-
批准年份:2026
-
负责人:
-
依托单位:
靶向递送一氧化碳调控AGE-RAGE级联反应促进糖尿病创面愈合研究
-
批准号:JCZRQN202500010
-
项目类别:省市级项目
-
资助金额:--
-
批准年份:2025
-
负责人:
-
依托单位:
对香豆酸抑制AGE-RAGE-Ang-1通路改善海马血管生成障碍发挥抗阿尔兹海默病作用
-
批准号:2025JJ70209
-
项目类别:省市级项目
-
资助金额:--
-
批准年份:2025
-
负责人:雷芬芳
-
依托单位:
AGE-RAGE通路调控慢性胰腺炎纤维化进程的作用及分子机制
-
批准号:--
-
项目类别:面上项目
-
资助金额:--
-
批准年份:2024
-
负责人:万荣
-
依托单位:
甜茶抑制AGE-RAGE通路增强突触可塑性改善小鼠抑郁样行为
-
批准号:2023JJ50274
-
项目类别:省市级项目
-
资助金额:--
-
批准年份:2023
-
负责人:贺志明
-
依托单位:
蒙药额尔敦-乌日勒基础方调控AGE-RAGE信号通路改善术后认知功能障碍研究
-
批准号:--
-
项目类别:地区科学基金项目
-
资助金额:33万元
-
批准年份:2022
-
负责人:都义日
-
依托单位:
补肾健脾祛瘀方调控AGE/RAGE信号通路在再生障碍性贫血骨髓间充质干细胞功能受损的作用与机制研究
-
批准号:--
-
项目类别:面上项目
-
资助金额:52万元
-
批准年份:2022
-
负责人:叶宝东
-
依托单位:
LncRNA GAS5在2型糖尿病动脉粥样硬化中对AGE-RAGE 信号通路上相关基因的调控作用及机制研究
-
批准号:
-
项目类别:省市级项目
-
资助金额:10.0万元
-
批准年份:2022
-
负责人:于海兵
-
依托单位:
围绕GLP1-Arginine-AGE/RAGE轴构建探针组学方法探索大柴胡汤异病同治的效应机制
-
批准号:81973577
-
项目类别:面上项目
-
资助金额:55.0万元
-
批准年份:2019
-
负责人:辛贵忠
-
依托单位:
AGE/RAGE通路microRNA编码基因多态性与2型糖尿病并发冠心病的关联研究
-
批准号:81602908
-
项目类别:青年科学基金项目
-
资助金额:18.0万元
-
批准年份:2016
-
负责人:刘括
-
依托单位: