UK MAD BEAMLINE AT ESRF

ESRF 的英国 MAD 光束线

• 批准号: G0500367/1
• 负责人: David Stuart
• 金额: $ 216.56万
• 依托单位: Medical Research Council
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2006
• 资助国家: 英国
• 起止时间: 2006 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0500367%2F1
• 关键词: UK; MAD; BEAMLINE; ESRF

Macromolecular crystallography is the most powerful method available to biologists to determine the precise three-dimensional arrangement of atoms within proteins and other complex biological molecules. By tuning the wavelength of X-rays such that they interact strongly with certain atoms within the molecule researchers can more easily unravel the complete structure. This method is called MAD and this grant asks for funds to provide open access to all UK researchers to one of the top MAD beamlines in Europe. The output of BM14 will be several hundred new structures some of which are likely to be of great biomedical importance.

大分子晶体学是生物学家用来确定蛋白质和其他复杂生物分子中原子精确三维排列的最有力的方法。通过调整X射线的波长，使它们与分子中的某些原子发生强烈的相互作用，研究人员可以更容易地解开整个结构。这种方法被称为MAD，这项拨款要求资金为所有英国研究人员提供欧洲顶级MAD光束线之一的开放访问。BM 14的产出将是数百个新结构，其中一些可能具有重要的生物医学意义。