Direct targets of Notch signalling activity
Notch 信号活动的直接目标
基本信息
- 批准号:G0500926/1
- 负责人:
- 金额:$ 33.29万
- 依托单位:
- 依托单位国家:英国
- 项目类别:Research Grant
- 财政年份:2006
- 资助国家:英国
- 起止时间:2006 至 无数据
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
For cells in the body to know what tissue they are part of, whether to grow, they need to communicate. The Notch receptor is central to one communication pathway and is essential for our bodies to be made with the right number and types of cell. It is also important throughout our lives because overactive Notch receptors are the cause of some cancers and defective Notch causes other diseases including types of dementia. In each cell-type in the body, only a small fraction of our genes are turned on. When Notch is active it results in additional genes being turned on. We are aiming to find out the identity of these additional genes and to investigate whether this can help us understand why Notch causes cells to change their behaviour and become cancerous. Our model is the fruit-fly Drosophila melanogaster, where Notch was first identified. Recent sequence of human and Drosophila genomes shows that over 2000 human disease genes are conserved in flies. As Drosophila has fewer genes, fewer cells and is easy to work with, it provides a good starting-point to identify genes that are important in cancers and that could be important therapeutic targets.
为了让体内的细胞知道它们是什么组织的一部分,是否要生长,它们需要交流。Notch受体是一种通讯途径的核心,对于我们的身体具有正确数量和类型的细胞至关重要。它在我们的生活中也很重要,因为过度活跃的Notch受体是某些癌症的原因,而有缺陷的Notch会导致其他疾病,包括痴呆症。在人体的每种细胞类型中,只有一小部分基因被激活。当Notch被激活时,它会导致额外的基因被激活。我们的目标是找出这些额外基因的身份,并调查这是否可以帮助我们理解为什么Notch会导致细胞改变行为并癌变。我们的模型是果蝇Drosophila melanogaster,Notch首次被发现。人类和果蝇基因组的最新序列显示,超过2000个人类疾病基因在果蝇中是保守的。由于果蝇的基因和细胞较少,并且易于处理,因此它为识别癌症中重要的基因以及可能成为重要治疗靶点的基因提供了一个很好的起点。
项目成果
期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Sarah Bray其他文献
Post-expressionist flies
后表现主义苍蝇
- DOI:
10.1038/35030286 - 发表时间:
2000-09-21 - 期刊:
- 影响因子:48.500
- 作者:
Sarah Bray;David Stein - 通讯作者:
David Stein
S12-03 The cytolinker Pigs is a target and a negative regulator of Notch signalling during epithelial somatic cell differentiation in the Drosophila ovary
- DOI:
10.1016/j.mod.2009.06.974 - 发表时间:
2009-08-01 - 期刊:
- 影响因子:
- 作者:
Mary Pines;Ben Housden;Fred Bernard;Sarah Bray;Katja Röper - 通讯作者:
Katja Röper
LONG-TERM EVOLOCUMAB USE IN SUBJECTS WITH HOMOZYGOUS AND SEVERE HETEROZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA: PRIMARY RESULTS OF THE TAUSSIG TRIAL
- DOI:
10.1016/s0735-1097(19)32321-6 - 发表时间:
2019-03-12 - 期刊:
- 影响因子:
- 作者:
Raul Santos;G. Kees Hovingh;Dirk Blom;Handrean Soran;Gerald Watts;J. Antonio Lopez;Sarah Bray;Christopher Kurtz;Andrew Hamer;Frederick Raal - 通讯作者:
Frederick Raal
EVOLOCUMAB USE IN PATIENTS WITH HUMAN IMMUNODEFICIENCY VIRUS AND DYSLIPIDEMIA: FINAL RESULTS OF THE OPEN LABEL EXTENSION PERIOD (BEIJERINCK)
- DOI:
10.1016/s0735-1097(21)02814-x - 发表时间:
2021-05-11 - 期刊:
- 影响因子:
- 作者:
Franck Boccara;Bruno Caramelli;Alexandra Calmy;Princy Kumar;J. Antonio G. Lopez;Sarah Bray;Marcoli Cyrille;Robert Rosenson - 通讯作者:
Robert Rosenson
HIV/AIDS-Research and Palliative Care
艾滋病毒/艾滋病研究和姑息治疗
- DOI:
10.2147/hiv - 发表时间:
2012 - 期刊:
- 影响因子:10.2
- 作者:
Sarah Bray;J. Gedeon;Ahsan Hadi;Ahmed Kotb;Tarun Rahman;Elaha Sarwar;A. Savelyeva;M. Sévigny;Celestin Bakanda;J. Birungi;Keith Chan;Sanni Yaya;R. Deonandan;Edward J Mills - 通讯作者:
Edward J Mills
Sarah Bray的其他文献
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{{ truncateString('Sarah Bray', 18)}}的其他基金
RESETTING AND SCULPTING THE NOTCH RESPONSE
重置和塑造陷波响应
- 批准号:
MR/T014156/1 - 财政年份:2020
- 资助金额:
$ 33.29万 - 项目类别:
Research Grant
Functional roles of the C2 phospholipid-binding domain in Notch ligands
Notch 配体中 C2 磷脂结合域的功能作用
- 批准号:
BB/P006175/1 - 财政年份:2017
- 资助金额:
$ 33.29万 - 项目类别:
Research Grant
Mechanisms of gene regulation by CSL-Notch
CSL-Notch 的基因调控机制
- 批准号:
BB/J008842/1 - 财政年份:2012
- 资助金额:
$ 33.29万 - 项目类别:
Research Grant
Systems Approach to Biological Research Studentship
生物研究学生资助的系统方法
- 批准号:
BB/H531851/1 - 财政年份:2010
- 资助金额:
$ 33.29万 - 项目类别:
Training Grant
The dynamics of gene regulatory networks induced by Notch activation
Notch激活诱导的基因调控网络动态
- 批准号:
BB/F00897X/1 - 财政年份:2008
- 资助金额:
$ 33.29万 - 项目类别:
Research Grant
Molecular and Genetic Characterization of the Drosophila Trans-acting Factor Elf-1
果蝇反式作用因子 Elf-1 的分子和遗传特征
- 批准号:
8917480 - 财政年份:1990
- 资助金额:
$ 33.29万 - 项目类别:
Standard Grant
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