Automatic Attention to Smoking Cues: Neural Correlates

自动注意吸烟线索：神经相关性

• 批准号: 7530166
• 负责人: DAVID E EVANS
• 金额: $ 8.33万
• 依托单位: H. LEE MOFFITT CANCER CTR & RES INST
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-02-01 至 2011-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7530166
• 关键词: Address; Affect; Anterior; Area; Arousal; Attention; Autonomic nervous system; Behavioral; Brain; Brain imaging; Brain region; Characteristics; Cigarette; Cognitive; Cues; Dependence; Development; Drug abuse; Emotions; Event; Exposure to; Functional Magnetic Resonance Imaging; Galvanic Skin Response; Heart Rate; Individual; Insula of Reil; Knowledge; Methodology; Methods; Motivation; Neurobiology; Nicotine Dependence; Participant; Patient Self-Report; Pharmaceutical Preparations; Positron-Emission Tomography; Predisposition; Process; Reaction Time; Relapse; Relative (related person); Research; Resolution; Role; Secondary to; Signal Transduction; Smoke; Smoker; Smoking; Smoking Behavior; Source; Specificity; Structure; Techniques; addiction; base; cingulate cortex; craving; cue reactivity; design; imaging modality; improved; indexing; millisecond; non-smoker; public health relevance; relating to nervous system; response; theories; treatment program

DESCRIPTION (provided by applicant): Cue reactivity paradigms have been used to study associative and attentional mechanisms involved in drug abuse. For instance, exposure to smoking-related cues (e.g., watching someone smoke a cigarette) has been found to evoke self-reported craving and autonomic nervous system arousal (e.g., heart-rate and skin conductance). The proposed research seeks to better understand brain dynamics involving the capture of attention by smoking cues in dependent smokers. The examination of event-related brain potentials (ERP) is for studying the brain during initial exposure to picture cues. Very little smoking cue reactivity research has utilized ERP methodology, and existing studies have not addressed automatic versus controlled processing, nor have they used brain source localization techniques. The proposed study will address these issues by comparing ERP component amplitudes in response to the initial presentation of infrequently presented smoking, neutral, positive affect, and negative affect pictures. While performing this smoking cue task, participants will be engaged in a demanding attention task that is not relevant to cue type, thereby reducing voluntary attention effects on cue processing. We propose to study neural correlates of automatic attention to smoking and neutral cues among smokers, former smokers, and nonsmokers (controls). It is hypothesized that smokers will have greater ERP component (N1, P2, and N2) amplitudes in response to smoking cues relative to neutral cues, and that this effect will not be present in former smokers and nonsmokers. It is also hypothesized that these ERP differences in cue reactivity will be associated with indices of current smoking behavior and nicotine dependence. Finally, we hypothesize that attention-related areas of the brain (e.g., anterior cingulate cortex and insular cortex) will be sources for smoking cue elicited components of the ERP waveform. PUBLIC HEALTH RELEVANCE: This study will contribute to greater understanding of automatic attentional processing in response to smoking cues among smokers. Knowledge obtained about how smoking-related cues initially activate neural processes among smokers may inform the development of treatment programs that target the unique characteristics of individual smokers.

描述（由申请人提供）：线索反应范式已被用于研究药物滥用中涉及的关联和注意机制。例如，暴露于吸烟相关的线索（例如，观察某人吸烟）已被发现引起自我报告的渴望和自主神经系统唤醒（例如，心率和皮肤电导）。这项拟议中的研究旨在更好地了解大脑动力学，包括依赖性吸烟者通过吸烟线索捕获注意力。事件相关脑电位（ERP）的检查是为了研究大脑在最初接触图片线索时的情况。很少有吸烟提示反应性研究利用ERP方法，现有的研究没有解决自动与控制处理，也没有使用脑源定位技术。拟议的研究将解决这些问题，通过比较ERP组件的振幅在响应于不经常提出的吸烟，中性，积极的影响，和消极的影响图片的初始介绍。在执行此吸烟提示任务时，参与者将参与与提示类型无关的高要求注意力任务，从而减少对提示处理的自愿注意力效应。我们建议研究吸烟者，前吸烟者和非吸烟者（对照组）之间的自动注意吸烟和中性线索的神经相关性。据推测，吸烟者将有更大的ERP组件（N1，P2和N2）的幅度在响应吸烟线索相对于中性线索，这种影响将不存在于前吸烟者和非吸烟者。也有人假设，这些ERP的线索反应性的差异将与目前的吸烟行为和尼古丁依赖的指数。最后，我们假设大脑中与注意力相关的区域（例如，前扣带皮层和岛叶皮层）将是吸烟提示诱发的ERP波形成分的来源。公共卫生关系：这项研究将有助于更好地了解自动注意加工的吸烟者之间的吸烟线索。关于吸烟相关线索最初如何激活吸烟者的神经过程的知识可能会为针对个体吸烟者独特特征的治疗方案的开发提供信息。