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Automatic Attention to Smoking Cues: Neural Correlates

自动注意吸烟线索：神经相关性

基本信息

批准号：
7761283
负责人：
DAVID E EVANS
金额：
$ 8.27万
依托单位：
H. LEE MOFFITT CANCER CTR & RES INST
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-02-01 至 2012-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7761283
关键词：
Address Affect Anterior Area Arousal Attention Autonomic nervous system Behavioral Brain Brain imaging Brain region Characteristics Cigarette Cognitive Cues Dependence Development Drug abuse Emotions Event Exposure to Functional Magnetic Resonance Imaging Galvanic Skin Response Heart Rate Individual Insula of Reil Knowledge Methodology Methods Motivation Neurobiology Nicotine Dependence Participant Patient Self-Report Pharmaceutical Preparations Positron-Emission Tomography Predisposition Process Reaction Time Relapse Relative (related person)Research Resolution Role Secondary to Signal Transduction Smoke Smoker Smoking Smoking Behavior Source Specificity Structure Techniques addiction base cingulate cortex craving cue reactivity design imaging modality improved indexing millisecond non-smoker public health relevance relating to nervous system response theories treatment program

项目摘要

DESCRIPTION (provided by applicant): Cue reactivity paradigms have been used to study associative and attentional mechanisms involved in drug abuse. For instance, exposure to smoking-related cues (e.g., watching someone smoke a cigarette) has been found to evoke self-reported craving and autonomic nervous system arousal (e.g., heart-rate and skin conductance). The proposed research seeks to better understand brain dynamics involving the capture of attention by smoking cues in dependent smokers. The examination of event-related brain potentials (ERP) is for studying the brain during initial exposure to picture cues. Very little smoking cue reactivity research has utilized ERP methodology, and existing studies have not addressed automatic versus controlled processing, nor have they used brain source localization techniques. The proposed study will address these issues by comparing ERP component amplitudes in response to the initial presentation of infrequently presented smoking, neutral, positive affect, and negative affect pictures. While performing this smoking cue task, participants will be engaged in a demanding attention task that is not relevant to cue type, thereby reducing voluntary attention effects on cue processing. We propose to study neural correlates of automatic attention to smoking and neutral cues among smokers, former smokers, and nonsmokers (controls). It is hypothesized that smokers will have greater ERP component (N1, P2, and N2) amplitudes in response to smoking cues relative to neutral cues, and that this effect will not be present in former smokers and nonsmokers. It is also hypothesized that these ERP differences in cue reactivity will be associated with indices of current smoking behavior and nicotine dependence. Finally, we hypothesize that attention-related areas of the brain (e.g., anterior cingulate cortex and insular cortex) will be sources for smoking cue elicited components of the ERP waveform. PUBLIC HEALTH RELEVANCE: This study will contribute to greater understanding of automatic attentional processing in response to smoking cues among smokers. Knowledge obtained about how smoking-related cues initially activate neural processes among smokers may inform the development of treatment programs that target the unique characteristics of individual smokers.

描述（由申请人提供）：提示反应范式已用于研究药物滥用中涉及的联想和注意机制。例如，发现暴露于与吸烟相关的线索（例如，观看某人吸烟）会引起自我报告的渴望和自主神经系统的唤醒（例如，心率和皮肤电导）。这项拟议的研究旨在更好地了解依赖吸烟者通过吸烟线索吸引注意力的大脑动态。事件相关脑电位 (ERP) 检查用于研究最初接触图片线索时的大脑。很少有吸烟线索反应性研究利用 ERP 方法，并且现有研究没有讨论自动处理与受控处理的比较，也没有使用脑源定位技术。拟议的研究将通过比较 ERP 分量振幅来解决这些问题，以响应不经常出现的吸烟、中性、积极情感和消极情感图片的初始呈现。在执行此吸烟提示任务时，参与者将从事与提示类型无关的高要求注意力任务，从而减少自愿注意对提示处理的影响。我们建议研究吸烟者、前吸烟者和非吸烟者（对照组）对吸烟的自动注意和中性线索的神经相关性。据推测，相对于中性线索，吸烟者对吸烟线索的 ERP 成分（N1、P2 和 N2）振幅会更大，并且这种效应不会出现在前吸烟者和非吸烟者中。还假设提示反应性的这些 ERP 差异将与当前吸烟行为和尼古丁依赖的指数相关。最后，我们假设大脑中与注意力相关的区域（例如前扣带皮层和岛叶皮层）将是吸烟提示引发的 ERP 波形成分的来源。公共健康相关性：这项研究将有助于更好地理解吸烟者对吸烟线索的自动注意力处理。关于吸烟相关线索最初如何激活吸烟者神经过程的知识可能有助于制定针对个体吸烟者独特特征的治疗方案。