Gene by Behavioral Environment Interactions in Chronic Periodontitis

慢性牙周炎的基因与行为环境的相互作用

• 批准号: 7923078
• 负责人: DEBORAH E POLK
• 金额: $ 12.11万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-30 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7923078
• 关键词: Address; Adopted; Adult; Appalachian Region; Area; Award; Behavior; Behavioral; Behavioral Genetics; Biological; Chronic; DNA; Data; Dental; Dental Schools; Dental caries; Development Plans; Disease; Environment; Environmental Risk Factor; Etiology; Faculty; Foundations; Funding; Genes; Genetic; Genome; Genotype; Goals; Grant; Immune response; Infection; Inflammation; Inflammatory Response; Information Management; Intervention; Intervention Studies; Knowledge; Lead; Literature; Measures; Medicine; Mentors; Microbe; Mouth Diseases; National Institute of Dental and Craniofacial Research; Oral cavity; Oral health; Participant; Pathway interactions; Patient Care; Patient Self-Report; Periodontal Diseases; Periodontal Ligament; Periodontitis; Play; Population; Positioning Attribute; Predisposition; Prevention; Preventive; Principal Investigator; Psychosocial Stress; Public Health; Public Health Schools; Recommendation; Reporting; Research; Research Personnel; Resources; Risk; Risk Assessment; Risk Factors; Role; Sampling; Sampling Studies; Scientist; Series; Side; Signal Transduction; Single Nucleotide Polymorphism; Smoking; Societies; Techniques; Testing; Training; Treatment outcome; United States National Institutes of Health; Universities; Work; alveolar bone; bone; burden of illness; career development; disorder risk; effective therapy; follow-up; gene environment interaction; genetic risk factor; genome wide association study; high risk; improved; innovation; interest; pathogen; patient oriented; programs; research study; statistics; therapy design

DESCRIPTION (provided by applicant): Scholar Candidate: Dr. Deborah Polk is a behavioral scientist on the faculty at the University of Pittsburgh School of Dental Medicine. Her work with the transdisciplinary Center for Oral Health Research in Appalachia (COHRA) has honed her interest in examining the interaction of genotypes with behavioral environments in chronic periodontitis. Her short-term goal is to gain fundamental knowledge regarding periodontal disease, genotype by environment statistical analysis, and the conduct of patient-oriented oral health research. Her long-term goal is to become an independent research scientist with a funded research program that identifies modifiable factors that could lead to effective treatments for and the prevention of chronic periodontitis. Environment: The University of Pittsburgh School of Dental Medicine has COHRA, an ongoing NIDCR-funded grant examining oral health. DNA samples from this study are included in the NIH's Gene and Environment Initiative genome-wide association study. The University of Pittsburgh has a long-standing track record of providing junior faculty with exceptional research and career development training. Mentor & Consultants: Dr. Mary Marazita, from the School of Dental Medicine, will serve as the primary mentor for this award. She is the principal investigator for COHRA and is an oral health geneticist. She will provide expertise in genetics and career development. Dr. Charles Sfeir, from the School of Dental Medicine, will serve as a consultant in chronic periodontitis. Dr. Candace Kammerer, from the Graduate School of Public Health, will serve as a consultant in data analytic techniques. Dr. Robert Weyant, Chair of the Department of Dental Public Health and Information Management will serve as a consultant in career development. Research Career Development Plan: In addition to formal coursework in periodontal disease, genetics, statistics, and scientific integrity, a series of tailored tutorials will be conducted with the mentor/consultants, which will focus on their areas of expertise. Research Study: Data will be collected from COHRA's high-risk Appalachian sample. Through NIH's ongoing genome-wide association study, single nucleotide polymorphisms associated with chronic periodontitis will be identified in these participants. Participants' smoking, chronic psychosocial stress, and chronic periodontitis will be assessed. The aim of this project is to identify genotype by behavioral environment interactions in chronic periodontitis. Results will provide a foundation for intervention research addressing chronic periodontitis.

描述（由申请人提供）：学者候选人：Deborah Polk博士是匹兹堡大学牙科医学院的一名行为科学家。她在阿巴拉契亚跨学科口腔健康研究中心（COHRA）的工作磨练了她对慢性牙周炎基因型与行为环境相互作用的研究兴趣。她的短期目标是获得有关牙周病的基础知识，通过环境统计分析进行基因分型，并开展以患者为导向的口腔健康研究。她的长期目标是成为一名独立的研究科学家，拥有一个资助的研究项目，确定可改变的因素，可能导致有效的治疗和预防慢性牙周炎。环境：匹兹堡大学牙科医学院有COHRA，这是一项正在进行的nidcr资助的口腔健康检查拨款。这项研究的DNA样本被纳入美国国立卫生研究院的基因与环境倡议全基因组关联研究。匹兹堡大学在为初级教师提供卓越的研究和职业发展培训方面有着悠久的历史。导师和顾问：来自牙科医学院的Mary Marazita博士将担任该奖项的主要导师。她是COHRA的首席研究员，也是口腔健康遗传学家。她将提供遗传学和职业发展方面的专业知识。来自牙科医学院的Charles Sfeir博士将担任慢性牙周炎的顾问。来自公共卫生研究生院的Candace Kammerer博士将担任数据分析技术方面的顾问。牙科公共卫生和信息管理系主席Robert Weyant博士将担任职业发展顾问。研究职业发展计划：除了牙周病、遗传学、统计学和科学诚信方面的正式课程外，还将与导师/顾问一起进行一系列量身定制的教程，这些教程将侧重于他们的专业领域。研究研究：数据将从COHRA的高风险阿巴拉契亚样本中收集。通过NIH正在进行的全基因组关联研究，将在这些参与者中确定与慢性牙周炎相关的单核苷酸多态性。参与者的吸烟、慢性心理压力和慢性牙周炎将被评估。本研究的目的是通过行为环境的相互作用来确定慢性牙周炎的基因型。研究结果将为慢性牙周炎的干预研究提供基础。