Regulation of the positional stability of neurons in the developing nervous system

发育中神经系统中神经元位置稳定性的调节

基本信息

  • 批准号:
    G0501187/1
  • 负责人:
  • 金额:
    $ 40.8万
  • 依托单位:
  • 依托单位国家:
    英国
  • 项目类别:
    Research Grant
  • 财政年份:
    2006
  • 资助国家:
    英国
  • 起止时间:
    2006 至 无数据
  • 项目状态:
    已结题

项目摘要

The nervous system is composed of clusters of neurons that communicate through a network of processes, sometimes called nerves. Neurons are large and complex cells that extend processes, sometimes metres long, to specific targets. Yet, while they extend these long processes, the cell bodies of the neurons must also find their own settling places within precise boundaries. This is important to build a functional nervous system: that like neurons cluster together at the appropriate place when at the same time extend processes to different parts of the body. Strangely enough, we don?t know how neurons do this but recent experiments suggest that their supporting cells, the glia, play a role in setting the boundaries. This is what I want to investigate. This is important if we want to understand how the nervous system is built, why things sometimes go wrong in development or adulthood and how to fix them. For example, recently people have been talking about the possibility of using stem cell therapy to repair the nervous system. These stem cells will be implanted in the nervous system and will have to migrate to the right position, be maintained there and extend processes. Should they not be maintained, they might prove counter-productive and perturb the nervous system they are supposed to cure.
神经系统由神经元簇组成,这些神经元通过过程网络(有时称为神经)进行通信。神经元是巨大而复杂的细胞,它们将过程延伸到特定的目标,有时长达几米。然而,当它们延长这些长过程时,神经元的细胞体也必须在精确的边界内找到自己的定居点。这对于建立一个功能性神经系统是很重要的:就像神经元在适当的地方聚集在一起,同时将过程扩展到身体的不同部位。奇怪的是,我们不?我们不知道神经元是如何做到这一点的,但最近的实验表明,它们的支持细胞,神经胶质细胞,在设定边界方面发挥了作用。这就是我想要调查的。如果我们想了解神经系统是如何构建的,为什么在发育或成年时有时会出错,以及如何修复它们,这一点很重要。例如,最近人们一直在谈论使用干细胞治疗来修复神经系统的可能性。这些干细胞将被植入神经系统,并且必须迁移到正确的位置,维持在那里并延伸过程。如果它们不被维持,它们可能会适得其反,扰乱它们应该治愈的神经系统。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Matthieu Vermeren其他文献

Temporal dichotomy of neutrophil function in acute liver injury and repair
急性肝损伤与修复中中性粒细胞功能的时间二分法
  • DOI:
    10.1016/j.jhepr.2025.101417
  • 发表时间:
    2025-07-01
  • 期刊:
  • 影响因子:
    7.500
  • 作者:
    Jennifer A. Cartwright;Philippe M.D. Potey;Eilidh Livingstone;Lara Campana;Philip J. Starkey Lewis;Magdalena E.M. Oremek;Naomi N. Gachanja;Giulia Rinaldi;Rhona E. Aird;Tak Yung Man;Anuruddika J. Fernando;Joanna P. Simpson;Natalie Z.M. Homer;Nicole Barth;Melisande Addison;Candice Ashmore-Harris;Maria Elena Candela;Alastair M. Kilpatrick;Matthieu Vermeren;Calum T. Robb;Adriano G. Rossi
  • 通讯作者:
    Adriano G. Rossi
Orienting axon growth: spinal nerve segmentation and surround-repulsion.
定向轴突生长:脊神经分割和周围排斥。
Urinary Clusterin is a Biomarker of Renal Epithelial Senescence and Predicts Human Kidney Disease Progression
尿簇集素是肾上皮衰老的生物标志物并可预测人类肾脏疾病进展
  • DOI:
    10.1016/j.ekir.2025.04.035
  • 发表时间:
    2025-07-01
  • 期刊:
  • 影响因子:
    5.700
  • 作者:
    David P. Baird;Maximilian Reck;Ross Campbell;Marie-Helena Docherty;Piotr P. Janas;Tilly Mason;Zenuida Mortuza;Matthieu Vermeren;Andy Nam;Wei Yang;Nathan Schurman;Claire Williams;Jamie P. Traynor;Patrick B. Mark;Katie J. Mylonas;Jeremy Hughes;Laura Denby;Bryan R. Conway;David A. Ferenbach
  • 通讯作者:
    David A. Ferenbach
PDGFRβsup+/sup cells play a dual role as hematopoietic precursors and niche cells during mouse ontogeny
PDGFRβsup+/sup 细胞在小鼠个体发育过程中作为造血前体细胞和龛细胞发挥双重作用。
  • DOI:
    10.1016/j.celrep.2022.111114
  • 发表时间:
    2022-07-19
  • 期刊:
  • 影响因子:
    6.900
  • 作者:
    Diana Sá da Bandeira;Alastair Morris Kilpatrick;Madalena Marques;Mario Gomez-Salazar;Telma Ventura;Zaniah Nashira Gonzalez;Dorota Stefancova;Fiona Rossi;Matthieu Vermeren;Chris Sebastiaan Vink;Mariana Beltran;Neil Cowan Henderson;Bongnam Jung;Reinier van der Linden;Harmen Jan George van de Werken;Wilfred F.J. van Ijcken;Christer Betsholtz;Stuart John Forbes;Henar Cuervo;Mihaela Crisan
  • 通讯作者:
    Mihaela Crisan
Semaphorin 7a is protective through immune modulation during acetaminophen-induced liver injury
  • DOI:
    10.1186/s12950-025-00429-x
  • 发表时间:
    2025-03-20
  • 期刊:
  • 影响因子:
    4.100
  • 作者:
    Eilidh J. Livingstone;Jennifer A. Cartwright;Lara Campana;Philip J. Starkey Lewis;Benjamin J. Dwyer;Rhona Aird;Tak Yung Man;Matthieu Vermeren;Adriano Giorgio Rossi;Luke Boulter;Stuart John Forbes
  • 通讯作者:
    Stuart John Forbes

Matthieu Vermeren的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

相似海外基金

Determinants of Coronavirus Fidelity in Replication and Pathogenesis
冠状病毒复制和发病机制保真度的决定因素
  • 批准号:
    8711280
  • 财政年份:
    2013
  • 资助金额:
    $ 40.8万
  • 项目类别:
Determinants of Coronavirus Fidelity in Replication and Pathogenesis
冠状病毒复制和发病机制保真度的决定因素
  • 批准号:
    8597862
  • 财政年份:
    2013
  • 资助金额:
    $ 40.8万
  • 项目类别:
Formation and regulation of the translating mRNP
翻译 mRNP 的形成和调节
  • 批准号:
    8609469
  • 财政年份:
    2013
  • 资助金额:
    $ 40.8万
  • 项目类别:
ATR-Chk1 signaling during embryonic and germ line development in C. elegans
秀丽隐杆线虫胚胎和种系发育过程中的 ATR-Chk1 信号传导
  • 批准号:
    8218081
  • 财政年份:
    2012
  • 资助金额:
    $ 40.8万
  • 项目类别:
ATR-Chk1 signaling during embryonic and germ line development in C. elegans
秀丽隐杆线虫胚胎和种系发育过程中的 ATR-Chk1 信号传导
  • 批准号:
    8415514
  • 财政年份:
    2012
  • 资助金额:
    $ 40.8万
  • 项目类别:
ATR-Chk1 signaling during embryonic and germ line development in C. elegans
秀丽隐杆线虫胚胎和种系发育过程中的 ATR-Chk1 信号传导
  • 批准号:
    8610930
  • 财政年份:
    2012
  • 资助金额:
    $ 40.8万
  • 项目类别:
Using Chemical Biology to Interfere with the Influenza Virus Life Cycle
利用化学生物学干扰流感病毒的生命周期
  • 批准号:
    8662161
  • 财政年份:
    2010
  • 资助金额:
    $ 40.8万
  • 项目类别:
In vivo Detection and Imaging of Epigenetic Histone Modifications and Modifying E
表观遗传组蛋白修饰和修饰 E 的体内检测和成像
  • 批准号:
    8269067
  • 财政年份:
    2010
  • 资助金额:
    $ 40.8万
  • 项目类别:
In vivo Detection and Imaging of Epigenetic Histone Modifications and Modifying E
表观遗传组蛋白修饰和修饰 E 的体内检测和成像
  • 批准号:
    8144800
  • 财政年份:
    2010
  • 资助金额:
    $ 40.8万
  • 项目类别:
Using Chemical Biology to Interfere with the Influenza Virus Life Cycle
利用化学生物学干扰流感病毒的生命周期
  • 批准号:
    7784147
  • 财政年份:
    2010
  • 资助金额:
    $ 40.8万
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了