Diagnostic Labeling: Effect on White Coat Hypertension

诊断标签：对白大衣高血压的影响

• 批准号: 7847490
• 负责人: TANYA M Spruill
• 金额: $ 15.62万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-15 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7847490
• 关键词: Academic Medical Centers; Address; Affect; Ambulatory Blood Pressure Monitoring; Anxiety; Behavioral; Biometry; Blood Pressure; Cardiovascular Diseases; Cardiovascular system; Categories; Clinic; Clinic Visits; Clinical; Clinical Trials Design; Conduct Clinical Trials; Consensus; Control Groups; Data; Detection; Development Plans; Diagnosis; Diagnostic; Economic Burden; Employee; Epidemiology; Evaluation; Exhibits; Feedback; Foundations; Future; Goals; Gold; Health Professional; Hypertension; Individual; International; Intervention; Joints; K-Series Research Career Programs; Label; Licensing; Master' s Degree; Measurement; Measures; Mediating; Mediator of activation protein; Medical Research; Mentors; Morbidity - disease rate; Normal Range; Participant; Patients; Persons; Physicians; Physiological; Population; Prevention; Process; Psychologist; Psychophysiology; Public Health Schools; Randomized; Randomized Controlled Trials; Research; Research Personnel; Research Project Grants; Rest; Risk; Role; Scientist; Screening Result; Screening procedure; Services; Testing; Theoretical model; Training; Universities; Work; Workplace; abstracting; base; cardiovascular risk factor; career; career development; cost; diagnostic accuracy; experience; health literacy; hypertension treatment; improved; member; mortality; multidisciplinary; normotensive; prevent; programs; psychologic; skills; therapy design; therapy development; white coat hypertension

DESCRIPTION (provided by applicant): The proposed career development award will enable Dr. Tanya Goyal to become an independent scientist with expertise in behavioral and psychological interventions for hypertension and cardiovascular disease. The applicant is a licensed clinical psychologist with experience in cardiovascular research. However, she has limited experience in the conduct of clinical trials with hypertensive patients and lacks some fundamental skills that are necessary for an independent research career; these skills are the focus of her short-term goals. A multidisciplinary team of mentors at Columbia University Medical Center, including Drs. Gerin, Pickering, Sloan, and Schwartz will provide training in: (1) randomized controlled trial design and analysis; (2) cardiovascular psychophysiology; (3) epidemiology; and (4) medical research dissemination. The career development plan also includes completion of a Master's degree in Biostatistics at the Columbia University Mailman School of Public Health. The applicant will conduct a research project to study the effects of diagnostic labeling on clinic blood pressure and white coat hypertension. Previous research has shown that a diagnosis (i.e., label) of hypertension is associated with subsequent increases in resting blood pressure, and preliminary work by the applicant has demonstrated a cross-sectional association between hypertension labeling and the white coat effect. The white coat effect may be particularly problematic in prehypertensives, because a small elevation in clinic blood pressure could result in crossing the diagnostic cutoff for hypertension, potentially leading to misdiagnosis and unnecessary treatment. The proposed study will examine effects of prehypertension labeling on clinic and ambulatory blood pressure, and will examine potential psychological mediators of these associations. Participants will be 100 newly identified prehypertensives who have never been labeled. They will be randomly assigned to two groups which are given different types of feedback about their initial blood pressure screening results, and will be followed for three months. This study will provide a foundation for the development of interventions targeting the manner of delivery of diagnostic information by physicians to patients. The long-term goal of this research is to develop strategies to reduce negative psychological and physiological consequences of labeling, and thus to improve the accuracy of diagnosis. (End of Abstract)

描述（由申请人提供）：拟议的职业发展奖将使 Tanya Goyal 博士成为一名独立科学家，在高血压和心血管疾病的行为和心理干预方面拥有专业知识。申请人是具有心血管研究经验的执业临床心理学家。然而，她对高血压患者进行临床试验的经验有限，缺乏独立研究生涯所需的一些基本技能；这些技能是她短期目标的重点。哥伦比亚大学医学中心的多学科导师团队，包括博士。 Gerin、Pickering、Sloan 和 Schwartz 将提供以下方面的培训：(1) 随机对照试验设计和分析； (2)心血管心理生理学； （三）流行病学； (4) 医学研究传播。职业发展计划还包括完成哥伦比亚大学梅尔曼公共卫生学院生物统计学硕士学位。申请人将开展一项研究项目，研究诊断标签对临床血压和白大衣高血压的影响。先前的研究表明，高血压的诊断（即标签）与随后的静息血压升高相关，并且申请人的初步工作已经证明了高血压标签与白大衣效应之间的横断面关联。白大衣效应在高血压前期可能尤其成问题，因为临床血压的小幅升高可能会导致超过高血压的诊断界限，从而可能导致误诊和不必要的治疗。拟议的研究将检查高血压前期标签对临床血压和动态血压的影响，并将检查这些关联的潜在心理调节因素。参与者将是 100 名新发现的高血压前期患者，他们从未被贴上标签。他们将被随机分配到两组，并获得有关其初始血压筛查结果的不同类型的反馈，并将进行为期三个月的跟踪。这项研究将为制定针对医生向患者提供诊断信息的方式的干预措施奠定基础。这项研究的长期目标是制定策略来减少标签带来的负面心理和生理后果，从而提高诊断的准确性。 （摘要完）