Brain function predictors and outcome of weight loss and weight loss maintenance

脑功能预测因素以及减肥和减肥维持的结果

• 批准号: 7892363
• 负责人: CARY R SAVAGE
• 金额: $ 38.98万
• 依托单位: UNIVERSITY OF KANSAS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-08 至 2012-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7892363
• 关键词: Address; Adult; Area; Behavioral; Biological Process; Body Weight decreased; Body mass index; Brain; Brain region; Chronic; Cues; Diet; Dietary Intervention; Eating; Eating Behavior; Energy Intake; Expenditure; Failure; Food; Functional Imaging; Functional Magnetic Resonance Imaging; Grant; Health Care Costs; Human; Hunger; Hyperphagia; Individual; Lead; Light; Magnetic Resonance Imaging; Maintenance; Measures; Morbidity - disease rate; Motivation; Neurobiology; Obesity; Outcome; Participant; Patient Self-Report; Pattern; Population; Process; Public Health; Reporting; Research Personnel; Scanning; Side; Stimulus; System; Visual; Weight; Weight maintenance regimen; Work; base; behavior measurement; effective intervention; neuromechanism; reinforcer; reward processing; weight loss intervention; weight maintenance

DESCRIPTION (provided by investigator): This is a revised application for an R01 grant entitled: Brain function predictors and outcome of weight loss and weight loss maintenance. Obesity rates are on the rise and associated with serious public health consequences and rising health care costs. Eating behavior is influenced by a convergence of processes in the brain, including homeostatic factors and motivational and reward processing. Motivational and reward processing are especially important contributors to overeating in humans. Our initial functional imaging studies have identified brain regions that respond differently to visual food cues in obese and healthy weight individuals, and are positively correlated with reports of hunger in obese participants. While shedding some light on mechanisms of overeating, many important questions remain. For instance, it is not yet known whether brain activation patterns change after dieting, or if they change differentially in successful and unsuccessful dieters. In addition, little is currently understood regarding biological processes that contribute to long-term maintenance of healthy weight. We will scan obese and healthy weight participants with a food motivation fMRI paradigm during a baseline state and after obese participants have completed a twelve- week diet-based weight loss intervention. Obese participants will then be followed though a 6-month weight maintenance period. The study will address three Specific Aims: 1. Characterize brain activation underlying increased food motivation and impulsive eating in obese individuals. 2. Identify brain activation changes and predictors of initial weight loss. 3. Identify brain activation predictors of weight loss maintenance. Findings from this study will have significant implications for understanding mechanisms of obesity, weight loss, and weight maintenance, and may ultimately lead to more effective interventions. PUBLIC HEALTH RELEVANACE: Results of this work are highly significant to public health and could lead to a better understanding of how differences in brain activation relate to obesity. Dietary interventions, while generally effective, do not work for everyone, and weight regain is a significant problem. Findings from this study will have significant implications for understanding mechanisms of obesity, weight loss, and weight maintenance, and may ultimately lead to more effective interventions.

描述（由研究者提供）：这是一份R01资助的修订申请，标题为：脑功能预测因素和体重减轻和体重维持的结果。肥胖率正在上升，并与严重的公共卫生后果和不断上升的医疗保健费用有关。饮食行为受到大脑中一系列过程的影响，包括体内平衡因素、动机和奖励过程。动机和奖励过程是导致人类暴饮暴食的重要因素。我们最初的功能成像研究已经确定了肥胖和健康体重个体的大脑区域对视觉食物线索的反应不同，并且与肥胖参与者的饥饿报告呈正相关。虽然对暴饮暴食的机制有所了解，但仍有许多重要问题有待解决。例如，我们还不知道节食后大脑的活动模式是否会改变，或者节食成功和不成功的人的大脑活动模式是否会发生不同的变化。此外，目前对有助于长期维持健康体重的生物过程知之甚少。我们将在基线状态和肥胖参与者完成了为期12周的以饮食为基础的减肥干预后，用食物动机fMRI范式扫描肥胖和健康体重参与者。肥胖的参与者随后将经历6个月的体重维持期。该研究将解决三个具体目标：1。描述肥胖个体增加的食物动机和冲动进食背后的大脑活动。2. 确定大脑活动变化和最初体重减轻的预测因素。3. 确定维持体重的大脑活动预测因子。这项研究的发现将对理解肥胖、体重减轻和体重维持的机制具有重要意义，并可能最终导致更有效的干预措施。公共卫生相关性：这项工作的结果对公共卫生非常重要，并可能导致更好地理解大脑激活差异与肥胖的关系。饮食干预虽然普遍有效，但并非对每个人都有效，体重反弹是一个重大问题。这项研究的发现将对理解肥胖、体重减轻和体重维持的机制具有重要意义，并可能最终导致更有效的干预措施。

项目成果

Resting-state brain connectivity after surgical and behavioral weight loss.

• DOI: 10.1002/oby.21119
• 发表时间: 2015-07
• 期刊: OBESITY
• 影响因子: 6.9
• 作者: Lepping, Rebecca J.;Bruce, Amanda S.;Francisco, Alex;Yeh, Hung-Wen;Martin, Laura E.;Powell, Joshua N.;Hancock, Laura;Patrician, Trisha M.;Breslin, Florence J.;Selim, Niazy;Donnelly, Joseph E.;Brooks, William M.;Savage, Cary R.;Simmons, W. Kyle;Bruce, Jared M.
• 通讯作者: Bruce, Jared M.

Brain function predictors and outcome of weight loss and weight loss maintenance.

大脑功能预测因素以及减肥和减肥维持的结果。

• DOI: 10.1016/j.cct.2014.12.008
• 发表时间: 2015
• 期刊: Contemporary clinical trials
• 影响因子: 2.2
• 作者: Szabo-Reed,AmandaN;Breslin,FlorenceJ;Lynch,AnthonyM;Patrician,TrishaM;Martin,LauraE;Lepping,RebeccaJ;Powell,JoshuaN;Yeh,Hung-WenHenry;Befort,ChristieA;Sullivan,Debra;Gibson,Cheryl;Washburn,Richard;Donnelly,JosephE;Savag
• 通讯作者: Savag

Obesity is associated with altered mid-insula functional connectivity to limbic regions underlying appetitive responses to foods.

• DOI: 10.1177/0269881117728429
• 发表时间: 2017-11
• 期刊: Journal of psychopharmacology (Oxford, England)
• 作者: Avery JA;Powell JN;Breslin FJ;Lepping RJ;Martin LE;Patrician TM;Donnelly JE;Savage CR;Simmons WK
• 通讯作者: Simmons WK

A comparison of functional brain changes associated with surgical versus behavioral weight loss.

• DOI: 10.1002/oby.20630
• 发表时间: 2014-02
• 期刊: OBESITY
• 影响因子: 6.9
• 作者: Bruce, Amanda S.;Bruce, Jared M.;Ness, Abigail R.;Lepping, Rebecca J.;Malley, Stephen;Hancock, Laura;Powell, Josh;Patrician, Trisha M.;Breslin, Florence J.;Martin, Laura E.;Donnelly, Joseph E.;Brooks, William M.;Savage, Cary R.
• 通讯作者: Savage, Cary R.