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中文摘要
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描述(由申请人提供):本申请是对 RFA-HL-08-007“年轻人体重控制的目标方法”的回应。正如 RFA 中所述,该应用程序将侧重于开发、完善和评估年轻人体重控制的行为方法,该应用程序的重点是增强长期减肥效果。与 RFA 一致,本申请中的年轻人被定义为 18-35 岁的个人。年轻人肥胖的患病率一直在增加,体重过重与许多慢性疾病有关,包括心血管疾病、糖尿病、多种癌症和许多肌肉骨骼问题。此应用程序的重点是开发和评估可能适合年轻人的干预措施,以在 24 个月的干预后改善减肥结果。因此,本研究的主要目的是检验包含技术成分的强化减肥干预 (EWLI) 与标准行为减肥干预 (SBWP) 相比,在 24 个月内是否能改善年轻人(18-35 岁)的减肥效果。其他目标包括检查这些干预措施对身体成分、身体脂肪分布、健身、体力活动、饮食摄入以及可能预测行为变化的行为/心理社会措施的变化。评估将在第 0、6、12、18 和 24 个月时进行。这项研究招募了 480 名超重和肥胖的年轻人(18-35 岁)。受试者将参加为期 24 个月的行为减肥计划,其中包括减少能量摄入和中等至剧烈强度的运动(从每周 100 分钟逐渐增加到 300 分钟)。受试者将被随机分配接受这种干预(SBWP)或这种干预与技​​术增强相结合(EWLI)。 EWLI 将每天收到短信提示,以加强对第 7 至 24 个月行为干预的遵守,并将从第 13 至 24 个月佩戴监视器,提供有关能量消耗和日常身体活动目标实现情况的实时反馈。据推测,与 SBWP 相比,EWLI 的这些技术增强将显着改善体重减轻、身体成分、身体脂肪分布、健身、体力活动和饮食摄入。相关性(参见说明):年轻人的肥胖率显着增加,并且该年龄段长期维持减肥的能力并不理想。因此,有必要制定和实施有效的干预措施来解决这一公共卫生问题,这也是本干预研究的重点。 (摘要完)
英文摘要
DESCRIPTION (provided by applicant): This application is in response to RFA-HL-08-007 "Targeted Approaches to Weight Control for Young Adults". As outlined in the RFA, this application will focus on development, refinement, and evaluation of a behavioral approach to weight control in young adults, with the focus of this application being on enhancing long-term weight loss. Consistent with the RFA, young adults for this application are defined as individuals 18-35 years of age. The prevalence of obesity in young adults has been increasing, and excessive body weight have been linked to numerous chronic conditions including cardiovascular disease, diabetes, many forms of cancer, and numerous musculoskeletal problems. The focus of this application is to develop and evaluate interventions that may be appropriate for young adults to improve weight loss outcomes following a 24 month intervention. Therefore, the primary aim of this study is to examine whether an enhanced weight loss intervention (EWLI) that includes technology components results in improved weight loss in young adults (18-35 years of age) compared to a standard behavioral weight loss intervention (SBWP) over a period of 24 months. Additional aims include examination of these interventions on changes in body composition, body fat distribution, fitness, physical activity, dietary intake, and behavioral/psychosocial measures that may be predictive of behavior change. Assessments will occur at 0, 6, 12,18, and 24 months. This study involves the recruitment of 480 overweight and obese young adults (18-35 years of age). Subjects will participate in a 24 month behavioral weight loss program that includes a reduction in energy ntake and moderate-to-vigorous intensity exercise (progressively increasing from 100 to 300 minutes per week). Subjects will be randomized to receive this intervention (SBWP) or this intervention in combination with technology enhancements (EWLI). EWLI will receive daily text messaging prompts to reinforce adherence to the behavioral intervention from months 7-24, and will wear a monitor from months 13-24 that provides real-time feedback on energy expenditure and achievement of daily physical activity goals. It is hypothesized that these technology enhancements to EWLI will significantly improve weight loss, body composition, body fat distribution, fitness, physical activity, and dietary intake compared to SBWP. RELEVANCE (See instructions): Obesity rates of young adults have significantly increased and the ability to sustain weight loss long-term in this age group has been less than desirable. Therefore, there is a need to develop and implement effective intervention initiatives to address this public health concern, which is the focus of this proposed intervention study. (End of Abstract)
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The Physiology of the Weight Reduced State Data Coordinating Center
The Physiology of the Weight Reduced State Data Coordinating Center
The Physiology of the Weight Reduced State Data Coordinating Center
The Physiology of the Weight Reduced State Data Coordinating Center
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