Enhanced Behavioral Intervention to Improve Long-Term Weight Loss in Young Adults

描述（由申请人提供）：本申请是对RFA-HL-08-007“年轻人体重控制的目标方法”的回应。正如RFA中概述的那样，该应用程序将侧重于开发、改进和评估年轻人体重控制的行为方法，重点是增强长期减肥效果。与RFA一致，本申请的年轻人定义为18-35岁的个人。年轻人中肥胖的流行率一直在上升，体重过重与许多慢性疾病有关，包括心血管疾病、糖尿病、多种癌症和许多肌肉骨骼问题。本应用程序的重点是开发和评估可能适合年轻人的干预措施，以改善24个月干预后的减肥结果。因此，本研究的主要目的是研究在24个月的时间里，与标准行为减肥干预（SBWP）相比，包括技术成分的增强型减肥干预（EWLI）是否能改善年轻人（18-35岁）的体重减轻。其他目的包括检查这些干预措施对身体组成、体脂分布、健康、身体活动、饮食摄入以及可能预测行为改变的行为/社会心理措施的变化。评估将在0、6、12、18和24个月进行。本研究招募了480名超重和肥胖的年轻人（18-35岁）。受试者将参加一个为期24个月的行为减肥计划，包括减少能量摄入和中等到高强度的运动（从每周100分钟逐渐增加到300分钟）。受试者将随机接受该干预（SBWP）或该干预与技术增强（EWLI）相结合。在7-24个月期间，EWLI每天都会收到短信提示，以加强对行为干预的坚持，并在13-24个月期间佩戴监视器，提供能量消耗和每日身体活动目标实现情况的实时反馈。据推测，与SBWP相比，这些技术增强的EWLI将显著改善体重减轻、身体成分、体脂分布、健康、身体活动和饮食摄入。相关性（见说明）：年轻人的肥胖率显著增加，该年龄组长期维持减肥的能力不太理想。因此，有必要制定和实施有效的干预措施，以解决这一公共卫生问题，这是本建议的干预研究的重点。（摘要结束）

DESCRIPTION (provided by applicant): This application is in response to RFA-HL-08-007 "Targeted Approaches to Weight Control for Young Adults". As outlined in the RFA, this application will focus on development, refinement, and evaluation of a behavioral approach to weight control in young adults, with the focus of this application being on enhancing long-term weight loss. Consistent with the RFA, young adults for this application are defined as individuals 18-35 years of age. The prevalence of obesity in young adults has been increasing, and excessive body weight have been linked to numerous chronic conditions including cardiovascular disease, diabetes, many forms of cancer, and numerous musculoskeletal problems. The focus of this application is to develop and evaluate interventions that may be appropriate for young adults to improve weight loss outcomes following a 24 month intervention. Therefore, the primary aim of this study is to examine whether an enhanced weight loss intervention (EWLI) that includes technology components results in improved weight loss in young adults (18-35 years of age) compared to a standard behavioral weight loss intervention (SBWP) over a period of 24 months. Additional aims include examination of these interventions on changes in body composition, body fat distribution, fitness, physical activity, dietary intake, and behavioral/psychosocial measures that may be predictive of behavior change. Assessments will occur at 0, 6, 12,18, and 24 months. This study involves the recruitment of 480 overweight and obese young adults (18-35 years of age). Subjects will participate in a 24 month behavioral weight loss program that includes a reduction in energy ntake and moderate-to-vigorous intensity exercise (progressively increasing from 100 to 300 minutes per week). Subjects will be randomized to receive this intervention (SBWP) or this intervention in combination with technology enhancements (EWLI). EWLI will receive daily text messaging prompts to reinforce adherence to the behavioral intervention from months 7-24, and will wear a monitor from months 13-24 that provides real-time feedback on energy expenditure and achievement of daily physical activity goals. It is hypothesized that these technology enhancements to EWLI will significantly improve weight loss, body composition, body fat distribution, fitness, physical activity, and dietary intake compared to SBWP. RELEVANCE (See instructions): Obesity rates of young adults have significantly increased and the ability to sustain weight loss long-term in this age group has been less than desirable. Therefore, there is a need to develop and implement effective intervention initiatives to address this public health concern, which is the focus of this proposed intervention study. (End of Abstract)