Cardiovascular Evaluation for the SHS Phase V

SHS V 期心血管评估

• 批准号: 7622596
• 负责人: RICHARD B DEVEREUX
• 金额: $ 16.5万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-08-10 至 2013-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7622596
• 关键词: 12p; 15 year old; Adult; Age; American Indians; Area; Arterial Fatty Streak; Atherosclerosis; Biology; Blood Vessels; Calories; Cardiac; Cardiovascular Abnormalities; Cardiovascular Diseases; Cardiovascular system; Carotid Arteries; Carotid Artery Plaques; Carotid Atherosclerotic Disease; Cessation of life; Characteristics; Chromosomes; Clinical; Cohort Studies; Communities; Complement component C1s; Development; Diabetes Mellitus; Echocardiography; Electrocardiogram; Energy Metabolism; Evaluation; Event; Family; Family Sizes; Family Study; Foundations; Functional disorder; Funding; Generations; Genes; Genetic; Heart; Heart Atrium; Heart Valve Diseases; Heritability; Heterogeneity; Hypertension; Hypertrophy; Individual; Investigation; Ischemia; Joints; Lead; Left; Left Ventricular Ejection Fraction; Left Ventricular Function; Left Ventricular Hypertrophy; Left Ventricular Mass; Measures; Medial; Methods; Myocardial; Myocardial Ischemia; North America; Organ; Overweight; Participant; Pathogenesis; Peripheral arterial disease; Phase; Phenotype; Pilot Projects; Population; Population Study; Prevalence; Progress Reports; Publications; Recruitment Activity; Relative (related person); Research Personnel; Risk Factors; Sampling; Structure; Structure of popliteal artery; Techniques; Thick; Time; Trees; Tribes; Ultrasonography; Ventricular; Work; abstracting; aged; base; cardiovascular risk factor; cohort; computerized; diabetic; diagnostic accuracy; follow-up; genetic linkage; hemodynamics; improved; indexing; member; mortality; non-diabetic; phase 3 study; phase 4 study; pre-clinical; pressure; prognostic; programs; voltage

DESCRIPTION (provided by applicant): Findings in the first 4 Strong Heart Study (SHS) exams (high rates of diabetes [DM] and cardiovascular [CV] events and heritability of arterial cardiac phenotypes [LOD=5.3 for left ventricular (LV) mass index on chromosome 12p]) identify SHS participants as being of unusual importance in understanding CV disease biology. Carotid exams in participants in SHS Phase IV showed substantial progression of atherosclerosis over 4 years and showed heritability of arterial size and stiffness. Phase IV echo's showed near doubling of 'LV hypertrophy and decline in LV function over 8 years from Phase II. Initial 17¿10 months follow-up showed CV events were predicted strongly by discrete carotid plaque but only weakly by intimal-medial thickness (IMT).In SHS Phase V, 3,060 members >15 years old in 3-generation families will be evaluated by carotid and popliteal ultrasound, computerized ECG and echo measures of LV geometry and function. The characteristics of the SHS population and strengths of the investigative groups lead us to focus this renewal to: 1) establish genetic linkage of carotid artery IMT and discrete plaques; 2) assess linkage of LV mass, geometry and newer measures of LV function; 3) examine heritability of ECG measures of cardiac conduction, voltage and repolarization; 4) assess heritability and linkage of popliteal artery IMT and discrete plaque as measures of peripheral arterial disease; 5) assess the separate and joint effects of DM, overweight and hypertension on development of LV hypertrophy and dysfunction over 4 years from the 4thSHS exam; 6) determine the impacts of DM, overweight and hypertension on progression of carotid IMT and discrete plaques since the 4th SHS exam; 7) relate change in ECG measures of LV hypertrophy Andre polarization to changes in echo LV mass and arterial structure and function; 8) assess the prognostic significance of arterial measures made during the 3rd SHS exam and extend analyses of prognostic significance of previously-measured echo and ECG variables; 9) evaluate changes of arterial structure and function in SHS pilot Family Study participants over 8 years and of echo findings over 12 years in cohort members in the SHS Family Study; 10) examine relations of popliteal artery IMT and discrete a thermos to prevalent overt and sub clinical peripheral arterial disease and CV risk factors and 11) evaluate relations of changes in ECG measures of LV hypertrophy, repolarization and ischemia to morbid and mortal events. (End of Abstract)

描述（由申请人提供）： 前4项强心研究（SHS）检查的结果（糖尿病[DM]和心血管[CV]事件的高发生率以及动脉心脏表型的遗传性[染色体12 p上左心室（LV）质量指数的LOD=5.3]）确定了SHS参与者在理解CV疾病生物学方面的异常重要性。SHS IV期受试者的颈动脉检查显示4年内动脉粥样硬化的实质性进展，并显示动脉大小和硬度的遗传性。IV期超声心动图显示，与II期相比，8年内左心室肥大和左心室功能下降几乎加倍。初始17？10个月随访显示，离散的颈动脉斑块对CV事件有很强的预测作用，而内膜中层厚度（IMT）的预测作用很弱。在SHS第五阶段，将对3代家庭中3,060名>15岁的成员进行颈动脉和腘动脉超声、计算机心电图和左室几何形状和功能的回声测量。SHS人群的特征和研究组的优势使我们将更新的重点放在：1）建立颈动脉IMT和离散斑块的遗传联系; 2）评估LV质量、几何形状和LV功能的新测量方法的联系; 3）检查心脏传导、电压和复极的ECG测量方法的遗传性; 4）评估腘动脉IMT和离散斑块作为外周动脉疾病指标的遗传性和联系; 5）评估自第4次SHS检查起4年内DM、超重和高血压对LV肥大和功能障碍发展的单独和联合影响; 6）确定自第4次SHS检查以来DM、超重和高血压对颈动脉IMT进展和离散斑块的影响; 7）将LV肥大Andre极化的ECG测量的变化与回波LV质量和动脉结构和功能的变化相关联; 8）评估第3次SHS检查期间进行的动脉测量的预后意义，并扩展对先前-9）评估SHS试点家庭研究参与者在8年内动脉结构和功能的变化，以及SHS家庭研究中队列成员在12年内的超声检查结果; 10）检查腘动脉IMT和离散动脉与普遍的显性和亚临床外周动脉疾病以及CV风险因素的关系，以及11）评价LV肥大、复极和缺血的ECG指标变化与病态和死亡事件的关系。(End摘要）