Cardiovascular Evaluation for the SHS Phase V

SHS V 期心血管评估

• 批准号: 8609108
• 负责人: RICHARD B DEVEREUX
• 金额: $ 2万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-08-10 至 2013-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8609108
• 关键词: 12p; 15 year old; Adult; American Indians; Area; Arterial Fatty Streak; Atherosclerosis; Biology; Blood Vessels; Calories; Cardiac; Cardiovascular Abnormalities; Cardiovascular Diseases; Cardiovascular system; Carotid Arteries; Carotid Artery Plaques; Carotid Atherosclerotic Disease; Cessation of life; Characteristics; Chromosomes; Clinical; Cohort Studies; Communities; Development; Diabetes Mellitus; Echocardiography; Electrocardiogram; Energy Metabolism; Evaluation; Event; Family; Family Sizes; Family Study; Foundations; Functional disorder; Funding; Generations; Genes; Genetic; Heart; Heart Atrium; Heart Valve Diseases; Heritability; Heterogeneity; Hypertension; Hypertrophy; Individual; Investigation; Ischemia; Joints; Lead; Left; Left Ventricular Ejection Fraction; Left Ventricular Function; Left Ventricular Hypertrophy; Left Ventricular Mass; Measures; Medial; Methods; Myocardial; Myocardial Ischemia; North America; Organ; Overweight; Participant; Pathogenesis; Peripheral arterial disease; Phase; Phenotype; Pilot Projects; Population; Population Study; Prevalence; Progress Reports; Publications; Recruitment Activity; Relative (related person); Research Personnel; Risk Factors; Sampling; Structure; Structure of popliteal artery; Techniques; Thick; Time; Trees; Tribes; Ultrasonography; Ventricular; Work; abstracting; aged; base; cardiovascular risk factor; cohort; computerized; diabetic; diagnostic accuracy; follow-up; genetic linkage; hemodynamics; improved; indexing; member; mortality; non-diabetic; phase 3 study; phase 4 study; pre-clinical; pressure; prognostic; programs; voltage

DESCRIPTION (provided by applicant): Findings in the first 4 Strong Heart Study (SHS) exams (high rates of diabetes [DM] and cardiovascular [CV] events and heritability of arterial cardiac phenotypes [LOD=5.3 for left ventricular (LV) mass index on chromosome 12p]) identify SHS participants as being of unusual importance in understanding CV disease biology. Carotid exams in participants in SHS Phase IV showed substantial progression of atherosclerosis over 4 years and showed heritability of arterial size and stiffness. Phase IV echo's showed near doubling of 'LV hypertrophy and decline in LV function over 8 years from Phase II. Initial 17¿10 months follow-up showed CV events were predicted strongly by discrete carotid plaque but only weakly by intimal-medial thickness (IMT).In SHS Phase V, 3,060 members >15 years old in 3-generation families will be evaluated by carotid and popliteal ultrasound, computerized ECG and echo measures of LV geometry and function. The characteristics of the SHS population and strengths of the investigative groups lead us to focus this renewal to: 1) establish genetic linkage of carotid artery IMT and discrete plaques; 2) assess linkage of LV mass, geometry and newer measures of LV function; 3) examine heritability of ECG measures of cardiac conduction, voltage and repolarization; 4) assess heritability and linkage of popliteal artery IMT and discrete plaque as measures of peripheral arterial disease; 5) assess the separate and joint effects of DM, overweight and hypertension on development of LV hypertrophy and dysfunction over 4 years from the 4thSHS exam; 6) determine the impacts of DM, overweight and hypertension on progression of carotid IMT and discrete plaques since the 4th SHS exam; 7) relate change in ECG measures of LV hypertrophy Andre polarization to changes in echo LV mass and arterial structure and function; 8) assess the prognostic significance of arterial measures made during the 3rd SHS exam and extend analyses of prognostic significance of previously-measured echo and ECG variables; 9) evaluate changes of arterial structure and function in SHS pilot Family Study participants over 8 years and of echo findings over 12 years in cohort members in the SHS Family Study; 10) examine relations of popliteal artery IMT and discrete a thermos to prevalent overt and sub clinical peripheral arterial disease and CV risk factors and 11) evaluate relations of changes in ECG measures of LV hypertrophy, repolarization and ischemia to morbid and mortal events. (End of Abstract)

描述（由申请人提供）： 前 4 项强心脏研究 (SHS) 检查的结果（糖尿病 [DM] 和心血管 [CV] 事件的高发生率以及动脉心脏表型的遗传力 [12p 染色体上左心室 (LV) 质量指数 LOD=5.3]）表明 SHS 参与者对于了解 CV 疾病生物学具有异常重要的作用。 SHS IV 期参与者的颈动脉检查显示，4 年来动脉粥样硬化明显进展，并显示了动脉尺寸和硬度的遗传性。第四阶段回声显示，与第二阶段相比，8 年来，左心室肥厚和左心室功能下降几乎翻倍。最初 17-10 个月的随访显示，离散颈动脉斑块对 CV 事件的预测能力较强，但内膜中层厚度 (IMT) 的预测能力较弱。在 SHS 第五阶段，将通过颈动脉和腘动脉超声、计算机心电图以及左心室几何形状和功能的回声测量来评估 3 代家庭中 3,060 名 >15 岁的成员。 SHS 人群的特征和研究小组的优势使我们将这一更新的重点放在：1）建立颈动脉 IMT 和离散斑块的遗传联系； 2) 评估左室质量、几何形状和新的左室功能测量之间的联系； 3) 检查心脏传导、电压和复极的心电图测量的遗传性； 4) 评估腘动脉 IMT 和离散斑块的遗传性和关联性，作为外周动脉疾病的衡量标准； 5) 评估从第 4 次 SHS 检查起 4 年内糖尿病、超重和高血压对左室肥厚和功能障碍发展的单独和联合影响； 6) 确定自第四次 SHS 检查以来糖尿病、超重和高血压对颈动脉 IMT 和离散斑块进展的影响； 7) 将左心室肥厚安德烈极化心电图测量值的变化与左心室回声质量以及动脉结构和功能的变化联系起来； 8) 评估第三次 SHS 检查期间进行的动脉测量的预后意义，并扩展先前测量的回波和心电图变量的预后意义的分析； 9) 评估 SHS 试点家庭研究参与者超过 8 年的动脉结构和功能变化以及 SHS 家庭研究队列成员超过 12 年的回声结果； 10) 检查腘动脉 IMT 和离散热水瓶与流行的明显和亚临床外周动脉疾病和 CV 危险因素的关系，11) 评估 LV 肥厚、复极和缺血的 ECG 测量值变化与病态和死亡事件的关系。 （摘要完）

项目成果

Codesigning a community-based participatory research project to assess tribal perspectives on privacy and health data sharing: A report from the Strong Heart Study.

编码一个基于社区的参与研究项目，以评估有关隐私和健康数据共享的部落观点：强大心脏研究的报告。

• DOI: 10.1093/jamia/ocac038
• 发表时间: 2022-05-11
• 期刊: JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
• 影响因子: 6.4
• 作者: Triplett, Cynthia;Fletcher, Burgundy J.;Taitingfong, Riley, I;Zhang, Ying;Ali, Tauqeer;Ohno-Machado, Lucila;Bloss, Cinnamon S.
• 通讯作者: Bloss, Cinnamon S.

Ethnic differences in arterial wave reflections and normative equations for augmentation index.

动脉波反射的种族差异和增强指数的规范方程。

• DOI: 10.1161/hypertensionaha.110.166348
• 发表时间: 2011-06
• 期刊: Hypertension (Dallas, Tex. : 1979)
• 作者: Chirinos JA;Kips JG;Roman MJ;Medina-Lezama J;Li Y;Woodiwiss AJ;Norton GR;Yasmin;Van Bortel L;Wang JG;Cockcroft JR;Devereux RB;Wilkinson IB;Segers P;McEniery CM
• 通讯作者: McEniery CM

Cadmium and cardiovascular risk.

镉和心血管风险。

• DOI: 10.1097/ede.0b013e31829f613c
• 发表时间: 2013
• 期刊: Epidemiology (Cambridge, Mass.)
• 作者: Tellez-Plaza,Maria;Guallar,Eliseo;Howard,BarbaraV;Navas-Acien,Ana
• 通讯作者: Navas-Acien,Ana