Therapist Effects in the Design, Analysis and Reporting of Psychotherapy Randomised Clinical Trials

心理治疗的临床试验在所有心理健康临床试验中占很大比例。然而，无论是在设计还是在分析中，都很少有人明确地将治疗师考虑在内。这对试验结果和结论的精确度、混杂性和普遍性具有严重影响。拟议的研究的目的是（i）审查目前的理解治疗师的影响，在设计，分析和报告的心理治疗试验和系统评价的心理治疗试验;（ii）调整和评估统计方法中使用的集群随机对照试验的背景下，以纳入治疗师的变化心理治疗试验的荟萃分析。这项研究将涉及对已发表的试验和模拟工作的数据进行二次分析。预计将根据这项工作对新的CONSORT非药理学试验报告指南进行评估，现有的MOOSE系统综述报告指南也将进行评估。预计这项工作将有助于提高未来心理治疗临床试验和心理治疗试验系统评价的质量。

Clinical trials of psychotherapies make up a significant proportion of all clinical trials carried out in mental health. Yet relatively few explicitly take the therapist into account either in the design or in the analysis. This has serious implications for the precision, confounding and generalisability of the trial results and conclusions. The proposed research aims to (i) to review current understanding of therapist effects in the design, analysis and reporting of psychotherapy trials and systematic reviews of psychotherapy trials; (ii) to adapt and evaluate statistical approaches used in the context of cluster RCTs in order to incorporate therapist variation in meta-analyses of psychotherapy trials. The research will involve the secondary analysis of data from published trials and simulation work. It is expected that the new CONSORT guidelines for the reporting non-pharmacological trials will be evaluated in light of this work, as will existing MOOSE guidelines for the reporting of systematic reviews. This work is anticipated to help raise the quality of future clinical trials of psychotherapies and systematic reviews of psychotherapy trials.