Effective connectivity of central response to IBS

描述（由申请人提供）： 虽然有一个快速扩展的技术，用于评估中枢和自主神经系统的活动，肠易激综合征（IBS）使用的技术，如功能磁共振成像和惊吓反射的调制，大型和复杂的数据集生成，使传统的统计方法的适用性有限，并增加了需要更复杂的分析策略。在该领域的实质性知识以及应用和发展最先进的和新兴的数据分析统计技术方面受过培训的研究科学家对于功能性胃肠道（GI）疾病科学的成功发展至关重要。目前，很少有功能性GI疾病研究人员有这种双重训练。这个指导临床科学家奖的目标是开发一个研究项目，将最先进的分析和设计技术应用于功能性胃肠道疾病的功能性脑成像和心理生理学研究。一种新兴的IBS生物心理社会疾病模型假定了与压力和恐惧有关的中枢神经系统机制的潜在改变。该研究的主要目的是通过更好的统计分析和网络建模，特别关注fMRI和实验心理生理学研究（包括惊吓范式和诱发反应电位），以提高对功能性GI疾病中枢过程的理解。研究的重点是神经网络建模方法的应用程序与不同的脑成像技术获得的复杂数据集，并将这些结果同时获得的心理，行为，自主措施。培训计划涉及新的定量方法的获取，开发和应用，如有效的连接建模和混合效应建模的功能磁共振成像和心理生理数据，并包括课程和指导培训神经科学，脑肠道相互作用的神经生物学，先进的生物统计学，神经工程和IBS的临床研究。拟议的研究计划包括对广泛的现有和正在进行的研究数据库进行新的分析，以及两项新的神经心理生理学研究，将为候选人提供一个机会，以研究在健康和疾病中观察到的认知，行为，情感和生理变化的神经解剖学和病理生理学基础，对IBS和相关功能障碍具有重要意义。

DESCRIPTION (provided by applicant): Although there is a rapidly expanding technology for assessing central and autonomic nervous system activity in irritable bowel syndrome (IBS) using techniques such as fMRI and modulation of the startle reflex, large and complex data sets are generated that render conventional statistical approaches of limited applicability and have increased the need for more sophisticated analytic strategies. Research scientists trained in both the substantive knowledge in the field as well as the application and development of state-of-the-art and emerging statistical techniques for data analysis are essential to successful advancements in the science of functional gastrointestinal (GI) disorders. Currently, few functional GI disorder researchers have this dual training. The goal of this Mentored Clinical Scientist Award is to develop a research program applying state of the art analysis and design techniques to functional brain imaging and psychophysiological studies in functional GI disorders. An emerging biopsychosocial disease model for IBS posits underlying alterations in central nervous system mechanisms involved in stress and fear. The primary aim of the research is to improve understanding of central processes in functional GI disorders through better statistical analysis and network modeling with particular attention toward fMRI and experimental psychophysiological studies (including startle paradigms and evoked-response potentials). The research focus is on the application of neural network modeling approaches to complex data sets obtained with different brain imaging techniques, and to relate these results to simultaneously obtained psychological, behavioral, autonomic measures. The training plan involves the acquisition, development and application of novel quantitative methods such as effective connectivity modeling and mixed-effects modeling for fMRI and psychophysiological data and includes coursework and mentored training in neuroscience, neurobiology of brain-gut interactions, advanced biostatistics, neuroengineering, and clinical research in IBS. The proposed research plan which includes new analyses of extensive existing and ongoing study databases,and two new neuropsychophysiological studies will provide the candidate an opportunity to investigate the neuroanatomical and pathophysiologic substrates of the cognitive, behavioral, affective and physiologic alterations observed in health and disease with major implications for IBS and related functional disorders.