HORMONES, DIET AND RISK OF OVARIAN CANCER
激素、饮食和卵巢癌风险
基本信息
- 批准号:7793461
- 负责人:
- 金额:$ 24.16万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:
- 资助国家:美国
- 起止时间:至
- 项目状态:未结题
- 来源:
- 关键词:AcetaminophenAddressAdultAgeAge-YearsAlcohol consumptionAnti Inflammatory AnalgesicsArchivesAspirinBiological AssayBlood specimenBody SizeBody mass indexC-reactive proteinCDKN2A geneCarbonCastesCellsCholineChronicDNADataDiagnosisDietDietary intakeDiseaseDoseE-CadherinEnrollmentEpithelial ovarian cancerEstradiolEtiologyFolateFundingGenesGenetic PolymorphismGonadal Steroid HormonesGrantHaplotypesHeightHip region structureHormonalHormonesInflammationInsulin-Like Growth Factor IInsulin-Like Growth-Factor Binding Protein 1Insulin-Like-Growth Factor I ReceptorIntakeInterleukin-6Malignant NeoplasmsMalignant neoplasm of ovaryMetabolismMethionineMethylenetetrahydrofolate reductase (NADPH)Non-Steroidal Anti-Inflammatory AgentsNurses&apos Health StudyNutrientOxidoreductaseParaffin EmbeddingParticipantPathway interactionsPharmaceutical PreparationsPhysical activityPlasmaPostmenopausePremenopauseProgesteroneProspective StudiesProteinsPublic HealthQuestionnairesResourcesRiskRisk FactorsSamplingShapesSomatomedinsSpecimenSteroidsTetrahydrofolatesTissue SampleTumor Necrosis Factor-alphaTumor TissueVariantVitamin B6Womancancer riskcase controlcohortdesignenergy balancefollow-upgenetic risk factorhuman TNF proteinhuman TNFRSF1A proteinimprovedinflammatory markerovarian neoplasmreceptortumortumor necrosis factor alpha receptor
项目摘要
DESCRIPTION (provided by applicant): We propose to conduct detailed analyses of hormone,
dietary, and genetic risk factors of ovarian cancer using data collected from the Nurses' Health study
(NHS) since 1976 and from the Nurses' Health study II (NHSII) since 1989. We expect that 857 castes
in NHS and 163 cases in NHSII will be confirmed by the 2006 follow-up cycle; approximately 25 percent
(n~250) of all cases will be pre-menopausal. Specifically we propose to evaluate early body shape (at
ages 5 and 10), body mass index at age 18, adult waist-to-hip ratio, height, physical activity and
inactivity, birthweight, dietary folate and related nutrients, and analgesic/anti-inflammatory medication
used in relation to ovarian cancer risk. In addition, we will determine whether birthweight, waist-to-hip
ratio, and analgestic medication use are associated with sex hormones such as estradiol and
progesterone. Further, using a nested case-control design, we will examine relationships of plasma
creactine protein, interleukin-6, and TNF-alpha receptor 2 with ovarian cancer using blood samples
collected from 32,826 NHS participants in 1989-1990 and 26,616 NHSII Participants in 1996-1998.
Using germline DNA from archived buffy coat, buccal cell specimens, or non-tumor tissue, we promise
to evaluate ovarian cancer risk in relation to genetic polymorphisms in the methlyene tetrahydrofolate
reductase (MTHFR) gene (667 C>T). We have established a bank of tumor tissue from women with
incident ovarian cancer. Using this resource we propose to examine the aberrant methalyation of
certain genes within ovarian tumors and to assess whether these aberrations are associated with
dietary intake of folate and other related nutrients. For some exposures, such a physical activity and
body mass index, we will be able to examine relations to ovarian cancer in greater detail than previous
studies; for other exposures, such as inflammatory markers, ours will be the first prospective study. A
major strength of this application is our ability to examine these factors prospectively and the availability
of over 25 years worth of questionnaire data, archived plasma and DNA samples and tumor tissue
samples from ovarian cancer cases. Finally the project will not only improve our understanding of
disease etiology, but also could have important public health implications because several of these risk
factors are modifiable.
描述(由申请人提供):我们建议对激素进行详细分析,
卵巢癌的饮食和遗传危险因素,使用从护士健康研究中收集的数据
(NHS)自1976年以来,从护士健康研究II(NHSII)自1989年以来。我们预计857个种姓
NHS和NHSII中的163例病例将在2006年随访周期得到证实;约25%
(n~250)所有病例将为绝经前。具体来说,我们建议评估早期的身体形状(在
5岁和10岁),18岁时的体重指数,成人腰臀比,身高,身体活动和
不活动、出生体重、膳食叶酸和相关营养素以及镇痛/抗炎药物
与卵巢癌风险有关。此外,我们将确定出生体重,腰臀比
比率和镇痛药物的使用与性激素如雌二醇和
孕酮此外,使用嵌套的病例对照设计,我们将研究血浆
使用血液样本的肌酐蛋白、白细胞介素-6和TNF-α受体2与卵巢癌的关系
从1989-1990年的32,826名NHS参与者和1996-1998年的26,616名NHSII参与者中收集。
使用来自存档血沉棕黄层、口腔细胞标本或非肿瘤组织的生殖系DNA,我们保证
评估卵巢癌风险与亚甲基四氢叶酸基因多态性的关系
还原酶(MTHFR)基因(667 C>T)。我们已经建立了一个肿瘤组织库,
意外卵巢癌利用这一资源,我们建议检查异常甲基化的
卵巢肿瘤中的某些基因,并评估这些畸变是否与
叶酸和其他相关营养素的饮食摄入。对于某些暴露,这种身体活动和
体重指数,我们将能够比以前更详细地检查与卵巢癌的关系
研究;对于其他暴露,如炎症标志物,我们将是第一个前瞻性研究。一
该应用程序的主要优点是我们能够前瞻性地检查这些因素,
超过25年的问卷调查数据,存档的血浆和DNA样本以及肿瘤组织
卵巢癌病例的样本。最后,该项目不仅将提高我们对
疾病病因,但也可能有重要的公共卫生影响,因为其中一些风险
因素是可以改变的。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Susan E Hankinson其他文献
Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer
全基因组关联研究确定了与胰腺癌易感性相关的 ABO 基因座的变体
- DOI:
10.1038/ng.429 - 发表时间:
2009-08-02 - 期刊:
- 影响因子:29.000
- 作者:
Laufey Amundadottir;Peter Kraft;Rachael Z Stolzenberg-Solomon;Charles S Fuchs;Gloria M Petersen;Alan A Arslan;H Bas Bueno-de-Mesquita;Myron Gross;Kathy Helzlsouer;Eric J Jacobs;Andrea LaCroix;Wei Zheng;Demetrius Albanes;William Bamlet;Christine D Berg;Franco Berrino;Sheila Bingham;Julie E Buring;Paige M Bracci;Federico Canzian;Françoise Clavel-Chapelon;Sandra Clipp;Michelle Cotterchio;Mariza de Andrade;Eric J Duell;John W Fox Jr;Steven Gallinger;J Michael Gaziano;Edward L Giovannucci;Michael Goggins;Carlos A González;Göran Hallmans;Susan E Hankinson;Manal Hassan;Elizabeth A Holly;David J Hunter;Amy Hutchinson;Rebecca Jackson;Kevin B Jacobs;Mazda Jenab;Rudolf Kaaks;Alison P Klein;Charles Kooperberg;Robert C Kurtz;Donghui Li;Shannon M Lynch;Margaret Mandelson;Robert R McWilliams;Julie B Mendelsohn;Dominique S Michaud;Sara H Olson;Kim Overvad;Alpa V Patel;Petra H M Peeters;Aleksandar Rajkovic;Elio Riboli;Harvey A Risch;Xiao-Ou Shu;Gilles Thomas;Geoffrey S Tobias;Dimitrios Trichopoulos;Stephen K Van Den Eeden;Jarmo Virtamo;Jean Wactawski-Wende;Brian M Wolpin;Herbert Yu;Kai Yu;Anne Zeleniuch-Jacquotte;Stephen J Chanock;Patricia Hartge;Robert N Hoover - 通讯作者:
Robert N Hoover
Susan E Hankinson的其他文献
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{{ truncateString('Susan E Hankinson', 18)}}的其他基金
Metabolomic profile of chronic distress in relation to diseases of aging across diverse populations
不同人群中与衰老疾病相关的慢性痛苦的代谢组学特征
- 批准号:
10584230 - 财政年份:2017
- 资助金额:
$ 24.16万 - 项目类别:
Endogenous hormones and postmenopausal breast cancer: Etiologic insights and improving risk prediction
内源性激素和绝经后乳腺癌:病因学见解和改进风险预测
- 批准号:
9899942 - 财政年份:2017
- 资助金额:
$ 24.16万 - 项目类别:
Assessing the role of androgens in breast cancer risk
评估雄激素在乳腺癌风险中的作用
- 批准号:
8692673 - 财政年份:2012
- 资助金额:
$ 24.16万 - 项目类别:
Assessing the role of androgens in breast cancer risk
评估雄激素在乳腺癌风险中的作用
- 批准号:
8273845 - 财政年份:2012
- 资助金额:
$ 24.16万 - 项目类别:
Assessing the role of androgens in breast cancer risk
评估雄激素在乳腺癌风险中的作用
- 批准号:
8517054 - 财政年份:2012
- 资助金额:
$ 24.16万 - 项目类别:
Leadership, Administration and Statisitical Analysis
领导、管理和统计分析
- 批准号:
7786701 - 财政年份:2010
- 资助金额:
$ 24.16万 - 项目类别:
Premonopausal Hormone Levels and Risk of Breast Cancer
绝经前激素水平和乳腺癌风险
- 批准号:
7844510 - 财政年份:2009
- 资助金额:
$ 24.16万 - 项目类别:
Modifiable Risk Factors and Gene/Environment interactions in Ovarian Cancer
卵巢癌中可改变的危险因素和基因/环境相互作用
- 批准号:
6991014 - 财政年份:2004
- 资助金额:
$ 24.16万 - 项目类别:
URINARY ESTROGEN METABOLITES AND BREAST CANCER RISK
尿液雌激素代谢物与乳腺癌风险
- 批准号:
6377888 - 财政年份:2000
- 资助金额:
$ 24.16万 - 项目类别:
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