University of Guam/Cancer Research Center of Hawaii Partnership (1 of 2)

关岛大学/夏威夷癌症研究中心合作伙伴（1 of 2）

• 批准号: 7786722
• 负责人: CARL-WILHELM E VOGEL
• 金额: $ 63.57万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-28 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7786722
• 关键词: University; Guam; Cancer; Research; Center

DESCRIPTION (provided by applicant): Oral cancer is the sixth leading cancer in the world, and ranks in the top three cancers in countries where betel nut (also known as areca nut) chewing is common. In Micronesia, a group of Pacific Islands where betel nut is frequently chewed, the risk of oral cancer is elevated, but quite variable across populations. For the period 1985-1998 (age-adjusted to the 1988 U.S. population), the prevalence per 100,000 ranged from 4.2 in Chuuk to 31.8 in Yap. In Guam, the incidence of mouth cancer per 100,000 population for the period 1997-2003, age-adjusted to the 2000 U.S. population, varied between 8.1 for Chamorros to 17.9 among other Micronesians. The disparity in oral cancer rates among these populations may be due to differences in betel nut chewing patterns. To investigate the effect of chewing patterns, we must be able to conduct studies on multiple Micronesian islands with differing chewing patterns. Previously, we developed a comprehensive betel nut assessment protocol and a protocol for detecting oral lesions on Guam. The overall objectives of the pilot study are to further develop and test these methods, and to demonstrate that they can be applied in a research study of betel nut use on an island other than Guam. A convenience sample of 100 Micronesians (50 men and 50 women) who are long-term betel nut users (regular use for at least 10 years) will be recruited from the island of Saipan in the Commonwealth of the Northern Mariana Islands (CNMI). We will collect data on betel nut use, presence of oral precancerous lesions, diet, demographics, anthropometry, medical history, and physical activity. The specific aims of this study are to: 1) collect information on betel nut use among study participants and other members of their families, 2) perform oral examinations, and biopsies, as needed, on study participants, 3) measure other health risks among this population, including obesity, high blood pressure, self-reported history of cardiovascular disease and diabetes, and unhealthy dietary practices and 4) examine associations of duration, frequency, and type of betel nut use with oral pre-cancers and with other health risks. This pilot project will help formulate the research methods for studying betel nut use and disease risk in Micronesia, and will provide the necessary preliminary data for a full multi-island study of betel nut use and the prevalence of oral lesions. Ultimately, a better understanding of these associations will provide important new directions for reduction of health risks through educational efforts and targeted intervention strategies.

描述（申请人提供）：口腔癌是世界上第六大癌症，在槟榔（也称为槟榔）咀嚼常见的国家中，口腔癌是前三大癌症。在密克罗尼西亚，一组经常咀嚼槟榔的太平洋岛屿，口腔癌的风险升高，但在人群中差异很大。1985-1998年期间（根据1988年美国人口调整年龄），患病率范围为每10万人4.2例（楚克）至31.8例（雅普）。在关岛，1997-2003年期间，按2000年美国人口年龄调整的每10万人口腔癌发病率从查莫罗人的8.1例到其他关岛人的17.9例不等。这些人群口腔癌发病率的差异可能是由于槟榔咀嚼模式的差异。为了研究咀嚼模式的影响，我们必须能够对具有不同咀嚼模式的多个密克罗尼西亚群岛进行研究。此前，我们制定了一个全面的槟榔评估协议和协议，用于检测关岛的口腔病变。试点研究的总体目标是进一步发展和测试这些方法，并表明这些方法可以应用于关岛以外的一个岛屿的槟榔使用研究。将从北方马里亚纳群岛联邦的塞班岛招募100名长期服用槟榔（定期服用至少10年）的密克罗尼西亚人（50名男性和50名女性）作为方便样本（CNMI）。我们将收集槟榔使用、口腔癌前病变、饮食、人口统计学、人体测量学、病史和体力活动的数据。这项研究的具体目标是：1）收集研究参与者及其家庭其他成员使用槟榔的信息，2）根据需要对研究参与者进行口腔检查和活检，3）测量该人群的其他健康风险，包括肥胖，高血压，自我报告的心血管疾病和糖尿病史，和不健康的饮食习惯和4）检查协会的持续时间，频率和类型的槟榔使用与口腔癌前病变和其他健康风险。这一试点项目将有助于制定研究方法，以研究密克罗尼西亚的槟榔使用和疾病风险，并将为多岛屿槟榔使用和口腔病变流行情况的全面研究提供必要的初步数据。最终，更好地了解这些关联将为通过教育努力和有针对性的干预战略减少健康风险提供重要的新方向。